Legume-derived bioactive peptides: role in cardiovascular disease prevention and control

IF 8.9 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
David Fonseca Hernandez , Luis Mojica , Elvira Gonzalez de Mejia
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Abstract

Cardiovascular diseases (CVDs) are a health problem worldwide. The use of peptides and protein hydrolysates derived from legumes to prevent and treat them has increased in recent years. In vitro and in vivo data support the efficacy of peptide interaction with markers associated with hypertension, endothelium dysfunction, and atherosclerosis. However, challenges such as misunderstanding their mechanism of action, safety, bioavailability, bitter taste, and cost-effective production limit their clinical and commercial translation. We analyzed and summarized recent findings related to legume-derived peptides and their mechanism of action associated with CVDs, including novel target markers associated with lipid metabolism, such as the inflammasome, angiopoietin-like protein 3, and proprotein convertase subtilisin/kexin 9.

Abstract Image

豆类生物活性肽:在心血管疾病防治中的作用
心血管疾病(CVDs)是世界性的健康问题。近年来,人们越来越多地使用从豆类中提取的肽和蛋白质水解物来预防和治疗心血管疾病。体外和体内数据支持肽与高血压、内皮功能障碍和动脉粥样硬化相关标志物相互作用的功效。然而,对其作用机制的误解、安全性、生物利用度、苦味以及成本效益生产等挑战限制了其临床和商业转化。我们分析并总结了有关豆科植物衍生肽及其与心血管疾病相关的作用机制的最新发现,包括与脂质代谢相关的新型靶标,如炎性体、血管生成素样蛋白 3 (ANGPLT3) 和丙蛋白转换酶亚基酶/kexin 9 (PCSK9)。
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来源期刊
Current Opinion in Food Science
Current Opinion in Food Science Agricultural and Biological Sciences-Food Science
CiteScore
18.40
自引率
4.00%
发文量
157
审稿时长
92 days
期刊介绍: Current Opinion in Food Science specifically provides expert views on current advances in food science in a clear and readable format. It also evaluates the most noteworthy papers from original publications, annotated by experts. Key Features: Expert Views on Current Advances: Clear and readable insights from experts in the field regarding current advances in food science. Evaluation of Noteworthy Papers: Annotated evaluations of the most interesting papers from the extensive array of original publications. Themed Sections: The subject of food science is divided into themed sections, each reviewed once a year.
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