Relationship of toll-like receptor 7, 9 and 10 polymorphisms on the severity of COVID-19

Abstract

COVID-19 is an pandemic that is still affecting today and has caused many deaths. Toll-like receptor (TLR) have an important role in the binding of disease agents to host cell, disease susceptibility and severity, host disease resistance, In this study, we investigated frequencies of TLR7 (C.4-151 A/G), TLR9 (T-1486C and G2848A), and TLR10 (720A/C and 992T/A) single nucleotide polymorphisms (SNPs) in 150 cases with COVID-19 and 171 control samples. We also observed whether TLR7, 9, and 10 were related with the COVID-19 disease severity. Furthermore, we analyzed the association between COVID-19 and some clinical parameters. Polymerase chain reaction (PCR) based on restriction fragment length polymorphism (RFLP) was performed for TLR7, 9 and 10 SNPs. TLR7 C.4-151 A/G G allele and GG genotype; TLR9 T-1486C C allele and TC, CC genotypes; and TLR10 720A/C C allele; TLR10 992T/A A allele and AA genotype frequencies were statistic significant in cases compared with controls (P<0.05*). In addition, there was a statistic significant difference in the distribution of TLR7, 9, and 10 allele and genotype frequencies between severity groups (P<0.05*). Our findings suggest that TLR7, 9, and 10 polymorphisms may be crucial on clinical course or susceptibility of the infection.