Relation of Langerhans cell size to buccal carcinoma.

IF 1.6 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Biotechnic & Histochemistry Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI:10.1080/10520295.2024.2305499
John Kandam Kulathu Mathew, Pranay Gaikwad, Rajadoss M K Pandian, Grace Rebekah, Suganthy Rabi
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引用次数: 0

Abstract

Oral cancer decreases quality of life despite timely medical management. The carcinogens in tobacco products and their role in tumorigenesis are well documented. Langerhans cells (LCs) are a subset of antigen-presenting cells (APCs) that monitor the tumor microenvironment and engulf carcinogens and foreign bodies. We investigated the distribution and size of LCs and their relation to the mode of tobacco consumption and clinical outcome in patients with buccal carcinoma. We recruited patients with oral cancer who were scheduled for tumor excision and men with urethral stricture undergoing substitution urethroplasty using buccal mucosa. Normal and tumor-adjacent tissues were stained with CD1a antibody. The distribution and mean diameter of 100 LCs/patient were determined. We found significantly smaller LCs in patients who chewed only tobacco compared to those who consumed tobacco by other means. The size of LCs decreased significantly with progressive stages of malignant disease. We found that patients with larger LCs survived longer than those with smaller LCs during an average follow-up of 24 months. We suggest a relation between the size of LCs and clinical outcomes in patients with buccal carcinoma.

朗格汉斯细胞大小与口腔癌的关系
尽管及时治疗,口腔癌仍会降低生活质量。烟草制品中的致癌物质及其在肿瘤发生过程中的作用已得到充分证实。朗格汉斯细胞(Langerhans cells,LCs)是抗原递呈细胞(APCs)的一个亚群,可监测肿瘤微环境并吞噬致癌物质和异物。我们研究了口腔癌患者体内朗格汉斯细胞的分布、大小及其与吸烟方式和临床结果的关系。我们招募了计划进行肿瘤切除术的口腔癌患者和使用口腔黏膜进行替代尿道成形术的尿道狭窄男性患者。用 CD1a 抗体对正常组织和肿瘤邻近组织进行染色。测定了 100 个 LCs/患者的分布和平均直径。我们发现仅咀嚼烟草的患者的 LCs 明显小于通过其他方式吸烟的患者。LCs 的大小随着恶性疾病的进展阶段而明显减小。我们发现,在平均 24 个月的随访中,LC 较大的患者比 LC 较小的患者存活时间更长。我们认为 LCs 的大小与口腔癌患者的临床预后有关。
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来源期刊
Biotechnic & Histochemistry
Biotechnic & Histochemistry 生物-生物工程与应用微生物
CiteScore
3.40
自引率
6.20%
发文量
46
审稿时长
6-12 weeks
期刊介绍: Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.
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