Role of anti-tubercular treatment in vitro fertilization (IVF)

Q3 Medicine
Kaberi Banerjee , Bhavana Singla , Priyanka Verma
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引用次数: 0

Abstract

Objective

To evaluate the role of anti-tubercular treatment (ATT) in vitro fertilization (IVF).

Design

Retrospective analysis.

Methods

A retrospective study was performed in 45 women suffering from infertility with a diagnosis of thin endometrium, history of repeated IVF failure, recurrent miscarriages or hysteroscopic or laparoscopic adhesiolysis in 4 years duration. Based on composite reference standard (CRS), in all females, Akt 4 Kit (combination of four medicines – Isoniazid 300 mg, rifampicin 450 mg, ethambutol 800 mg and pyrazinamide 750 mg) was started for 2 months with supportive medicines followed by AKT 2 (combination of two medicines – Isoniazid 300 mg and rifampicin 450 mg) for 4 months. Fertility treatment was started after 2 months of Akt 4 medication. In all cases, frozen embryo transfer was planned with tab estradiol valerate 6–8 mg in divided doses followed by endometrial thickness scanning. In all cases, embryo transfer was planned when endometrial thickness >8 mm in transvaginal scanning. The efficacy of ATT in above cases was evaluated by assessing the endometrium thickness before embryo transfer, pregnancy rates and clinical pregnancy rates.

Results

There was no significant difference regarding demographic variables, egg reserve, sperm parameters, number of embryos transferred and embryo quality in all cases. Out of 45 cases, the pregnancy was positive in 31 cases (Pregnancy rate – 68.8 %). The clinical pregnancy rate was 64.4 % (29/45).

Conclusion

There is a significant role of anti-tubercular treatment (ATT) in infertility in case of thin endometrium not responsive to medications, repeated IVF failure, recurrent miscarriages or hysteroscopic or laparoscopic adhesiolysis. It improved the endometrial thickness, pregnancy rate and the clinical pregnancy rate in IVF. But further studies are needed with large sample size to collaborate our findings.
抗结核治疗在体外受精(IVF)中的作用
目的探讨抗结核治疗在体外受精(IVF)中的作用。DesignRetrospective分析。方法回顾性分析45例子宫内膜薄、多次IVF失败、反复流产或宫腔镜或腹腔镜粘连松解的不孕症患者4年的临床资料。根据综合参考标准(CRS),在所有女性患者中,Akt 4 Kit(联合使用四种药物-异烟肼300 mg、利福平450 mg、乙胺丁醇800 mg和吡嗪酰胺750 mg)开始治疗2个月,并给予支持药物,随后Akt 2(联合使用两种药物-异烟肼300 mg和利福平450 mg)治疗4个月。Akt - 4治疗2个月后开始生育治疗。在所有病例中,冷冻胚胎移植计划使用戊酸雌二醇6-8 mg分次注射,然后进行子宫内膜厚度扫描。在所有病例中,经阴道扫描子宫内膜厚度为8mm时计划进行胚胎移植。通过评估胚胎移植前子宫内膜厚度、妊娠率和临床妊娠率来评价ATT对上述病例的疗效。结果所有病例在人口学变量、卵子储备、精子参数、移植胚胎数和胚胎质量方面差异无统计学意义。45例中妊娠阳性31例(妊娠率- 68.8%)。临床妊娠率为64.4%(29/45)。结论抗结核治疗在子宫内膜薄、药物无反应、IVF反复失败、反复流产或宫腔镜、腹腔镜粘连松解的不孕症中有重要作用。改善子宫内膜厚度,提高妊娠率,提高体外受精临床妊娠率。但需要进一步的大样本研究来配合我们的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Indian Journal of Tuberculosis
Indian Journal of Tuberculosis Medicine-Infectious Diseases
CiteScore
2.80
自引率
0.00%
发文量
103
期刊介绍: Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline
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