Rendimiento diagnóstico de la escala BROC2ULIS-65 comparada con CURB-65 en pacientes hospitalizados por neumonía

Abstract

Community-acquired pneumonia (CAP) is one of the most common and potentially fatal infectious diseases in daily practice. 40% of patients require admission to hospitalization and 5% of these require admission to the intensive care unit.

Methods

A cross-sectional retrospective cohort study was carried out, of patients treated between 2018 and 2022 for community-acquired pneumonia (CAP) at the Hospital Departamental San Antonio de Padua, including 241 patients in whom their mortality outcome was known.

Statistical analysis

They were analyzed with the statistical package STATA 17.0, the BROC2ULIS-65 index was constructed and compared with the CURB-65 standard and lactate for the measurement of CAP severity. Finally, an analysis of the area under the receiver operating characteristic curve (ACOR) was performed, calculating a 95% confidence interval. The Helsinki ethical recommendations and resolution 8430 of 1993 for research in humans were followed, as well as the confidentiality and protection of data.

Results

Of the 241 patients included in the final analysis, 56.02% were male, 56.85% of the patients were older than 65 years, with a mean age of 65.65 years (16.84), the minimum of 20 years and the maximum of 96 years. Both risk scores (BROC2ULIS-65 and CURB-65) showed statistically significant differences with P = .001 between patients with CAP who died and those who did not. After performing a Spearman correlation test, it was found that there was a significant linear correlation (P = .001) between the BROC2ULIS-65 value and the CURB-65. The BROC2ULIS-65 score equal to or greater than 6 correctly classified 70.54% of patients with a specificity of 87.79% and a positive likelihood ratio (LR+) of 2.25.

Conclusions

The BROC2ULIS-65 scale with a score greater than or equal to 6 correctly classified 70.54% of the patients with a specificity of 87.79% and a LR+ of 2.25; with AUC 0.638 compared to 0.635 of the CURB-65, respectively.