Ningning Zhang, Pablo Domínguez de María, Selin Kara
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引用次数: 3
Abstract
Biocatalysis holds immense potential for pharmaceutical development as it enables synthetic routes to various chiral building blocks with unparalleled selectivity. Therein, solvent and water use account for a large contribution to the environmental impact of the reactions. In the spirit of Green Chemistry, a transition from traditional highly diluted aqueous systems to intensified non-aqueous media to overcome limitations (e.g., water shortages, recalcitrant wastewater treatments, and low substrate loadings) has been observed. Benefiting from the spectacular advances in various enzyme stabilization techniques, a plethora of biotransformations in non-conventional media have been established. Deep eutectic solvents (DESs) emerge as a sort of (potentially) greener non-aqueous medium with increasing use in biocatalysis. This review discusses the state-of-the-art of biotransformations in DESs with a focus on biocatalytic pathways for the synthesis of active pharmaceutical ingredients (APIs). Representative examples of different enzyme classes are discussed, together with a critical vision of the limitations and discussing prospects of using DESs for biocatalysis.
生物催化在医药开发方面具有巨大的潜力,因为它能以无与伦比的选择性合成各种手性构件。其中,溶剂和水的使用对反应的环境影响很大。本着绿色化学的精神,人们已经从传统的高度稀释水性体系过渡到强化的非水性介质,以克服各种限制(如水资源短缺、难处理的废水处理和低底物负荷)。得益于各种酶稳定技术的巨大进步,在非常规介质中进行生物转化的方法层出不穷。深共晶溶剂(DES)作为一种(潜在的)更环保的非水介质,在生物催化中的应用越来越广泛。本综述讨论了 DESs 中生物转化的最新进展,重点是合成活性药物成分 (API) 的生物催化途径。文中讨论了不同酶类的代表性实例,并对使用 DES 进行生物催化的局限性进行了深入探讨,同时还讨论了使用 DES 进行生物催化的前景。
期刊介绍:
Catalysts (ISSN 2073-4344) is an international open access journal of catalysts and catalyzed reactions. Catalysts publishes reviews, regular research papers (articles) and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.