Association between Brain White Matter Lesions and Disease Activity in HAM/TSP Patients

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-01-22 DOI:10.3390/neurolint16010013

K. Tamaki, S. Ouma, Nobutaka Takahashi, S. Fujioka, Yoshio Tsuboi

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Abstract

Human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients may have brain white matter (WM) lesions, but the association of these lesions with disease activity is poorly understood. We retrospectively evaluated the brain WM lesions of 22 HAM/TSP patients (male 4: female 18) including 5 rapid progressors, 16 slow progressors, and 1 very slow progressor. The severity of WM brain lesions on axial Fluid Attenuated Inversion Recovery images was evaluated utilizing the Fazekas scale, cerebrospinal fluid biomarkers, and proviral load in peripheral blood mononuclear cells. Imaging and biological data were compared at the first visit and a subsequent visit more than 4 years later. Patients with comorbidities including adult T-cell leukemia–lymphoma and cerebrovascular disease were excluded. The results revealed that brain WM lesions in the rapid progressors group were more pronounced than those in slow progressors. In patients with HAM/TSP, severe and persistent inflammation of the spinal cord may cause brain WM lesions.

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HAM/TSP患者脑白质病变与疾病活动性之间的关系

人类 T 细胞白血病病毒 1 型相关脊髓病/特发性痉挛性截瘫（HAM/TSP）患者可能会出现脑白质（WM）病变，但这些病变与疾病活动性的关系却鲜为人知。我们对 22 名 HAM/TSP 患者（男性 4 人：女性 18 人）的脑白质病变进行了回顾性评估，其中包括 5 名进展迅速者、16 名进展缓慢者和 1 名进展非常缓慢者。利用法泽卡斯量表、脑脊液生物标记物和外周血单核细胞中的病毒载量评估了轴向流体衰减反转恢复图像上脑部 WM 病变的严重程度。对首次就诊和 4 年多后再次就诊时的成像和生物数据进行了比较。排除了患有成人T细胞白血病-淋巴瘤和脑血管疾病等合并症的患者。结果显示，快速进展组的脑WM病变比缓慢进展组更为明显。在 HAM/TSP 患者中，脊髓的严重和持续炎症可能会导致脑 WM 病变。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico