Evaluation of Absolute Neutrophil Count in the Perioperative Setting of Sarcoma Resection

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-24 DOI:10.1155/2024/4873984

Gayathri Vijayakumar, Emma M. Steffer, Neil Buac, Matthew W. Colman, S. Gitelis, Alan T. Blank

{"title":"Evaluation of Absolute Neutrophil Count in the Perioperative Setting of Sarcoma Resection","authors":"Gayathri Vijayakumar, Emma M. Steffer, Neil Buac, Matthew W. Colman, S. Gitelis, Alan T. Blank","doi":"10.1155/2024/4873984","DOIUrl":null,"url":null,"abstract":"Introduction. Limb salvage surgery (LSS) is the preferred surgical treatment for bone sarcomas. Preoperatively, many patients receive chemotherapy and may develop neutropenia. No study has evaluated the effect of a low preoperative absolute neutrophil count (ANC) on postoperative outcomes following LSS. Methods. This was a retrospective review of 114 patients who underwent LSS for bone sarcoma from 2010 to 2020. Preoperative lab values were analyzed by logistic regression to identify the risk of developing surgical complications within 30 days, surgical site infection (SSI), and reoperation. Results. Three (2.6%) patients experienced a surgical complication within 30 days. Twelve (10.53%) patients experienced postoperative SSI. Twenty-nine (25.4%) required reoperation. Preoperative ANC was not a significant predictor of surgical complications within 30 days, SSI, or reoperation. The only independent predictor of worse overall survival was the presence of a pathologic fracture at the time of surgery. Conclusion. This is the first study to evaluate preoperative ANC on postoperative outcomes following LSS. We report no significant differences in surgical complications within 30 days, SSI, or reoperation with low preoperative ANC. Future studies with larger cohorts of neutropenic patients are needed to evaluate these outcomes, as our cohort had very few neutropenic patients due to selection bias.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2024/4873984","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction. Limb salvage surgery (LSS) is the preferred surgical treatment for bone sarcomas. Preoperatively, many patients receive chemotherapy and may develop neutropenia. No study has evaluated the effect of a low preoperative absolute neutrophil count (ANC) on postoperative outcomes following LSS. Methods. This was a retrospective review of 114 patients who underwent LSS for bone sarcoma from 2010 to 2020. Preoperative lab values were analyzed by logistic regression to identify the risk of developing surgical complications within 30 days, surgical site infection (SSI), and reoperation. Results. Three (2.6%) patients experienced a surgical complication within 30 days. Twelve (10.53%) patients experienced postoperative SSI. Twenty-nine (25.4%) required reoperation. Preoperative ANC was not a significant predictor of surgical complications within 30 days, SSI, or reoperation. The only independent predictor of worse overall survival was the presence of a pathologic fracture at the time of surgery. Conclusion. This is the first study to evaluate preoperative ANC on postoperative outcomes following LSS. We report no significant differences in surgical complications within 30 days, SSI, or reoperation with low preoperative ANC. Future studies with larger cohorts of neutropenic patients are needed to evaluate these outcomes, as our cohort had very few neutropenic patients due to selection bias.

查看原文本刊更多论文

肉瘤切除术围手术期绝对中性粒细胞计数评估

导言。肢体挽救手术（LSS）是骨肉瘤的首选手术治疗方法。术前，许多患者接受化疗，可能会出现中性粒细胞减少。目前还没有研究评估术前绝对中性粒细胞计数（ANC）偏低对 LSS 术后疗效的影响。方法。这是一项回顾性研究，研究对象是2010年至2020年因骨肉瘤接受LSS手术的114名患者。通过逻辑回归分析术前化验值，以确定30天内出现手术并发症、手术部位感染（SSI）和再次手术的风险。结果。3名患者（2.6%）在30天内出现手术并发症。12名患者（10.53%）术后出现 SSI。29名患者（25.4%）需要再次手术。术前 ANC 不是 30 天内手术并发症、SSI 或再次手术的重要预测因素。手术时出现病理性骨折是导致总生存率降低的唯一独立预测因素。结论。这是第一项评估 LSS 术前 ANC 对术后结果影响的研究。我们报告称，术前ANC低的患者在30天内的手术并发症、SSI或再次手术方面没有明显差异。由于选择偏差，我们的队列中只有极少数中性粒细胞增多的患者，因此今后需要对更多的中性粒细胞增多患者进行研究，以评估这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.