The infusion of Baccharis spicata(Lam.) Baill (Asteraceae) has antiviral activity againsthepatitis B virus without cytotoxic effects against several cell lines

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-01-30 DOI:10.37360/blacpma.24.23.1.11

Joseph T Ortega, Ignacio Agudelo, R. Ricco, L. Cavallaro, Rodolfo Campos

引用次数: 0

Abstract

Medicinal plants are used to cure diseases, and their replacement is frequent and affects public health. The genus Baccharis has representatives within the medicinal flora of Argentina, although the replacement of the species of this genus known under the vulgar name of "carqueja" by Baccharis spicata has been detected in herbalists or markets of herbal products. The genotoxic safety of this species has been established in previous work of our group. The aim of this study was to evaluate the antiviral activity of an infusion made from B. spicata leaves against hepatitis B virus with the HepG2.2.15 cellular system and to determine cytotoxicity in HepG2.2,15, A549 and Vero cell lines. Infusion of B. spicata was active to inhibit HBV replication with an EC50of 22.54 μg/mL and a CC50of 190 μg/mL.

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百日草（菊科）泡腾片对乙型肝炎病毒具有抗病毒活性，对多种细胞株无细胞毒性作用

药用植物被用来治疗疾病，它们经常被替代，影响公众健康。在阿根廷的药用植物群中，辣根属（Baccharis）有其代表，但在草药商或草药产品市场上，已经发现以 "carqueja "为俗名的辣根属物种被辣根取代的情况。我们小组之前的研究已经确定了该物种的遗传毒性安全性。本研究的目的是通过 HepG2.2.15 细胞系统评估刺叶巴戟叶泡腾片对乙型肝炎病毒的抗病毒活性，并确定 HepG2.2.15、A549 和 Vero 细胞系的细胞毒性。灌注刺五加叶能有效抑制 HBV 复制，EC50 为 22.54 μg/mL，CC50 为 190 μg/mL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.