Bioactivity of Myrtus communis from the Montenegro coastline

IF 0.7 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE
Dusan Bugarin, D. Mitić-Ćulafić, E. Svirčev, M. Šundiċ, Neda M Mimica-Dukic
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引用次数: 0

Abstract

Although numerous studies have demonstrated the biomedical potential of Myrtus communisL., (Myrtaceae) data on myrtle from Montenegro are scarce. To evaluate antioxidant, antimutagenic and antibacterial activity of myrtle methanolic extracts. Antioxidant activity was evaluated by measuring free radicals scavenging activity, reducing power and enzyme inhibition. The strongest scavenging activity was towards DPPH radical (2,2-diphenyl-1-picrylhydrazyl) (IC501.69-2.25 mg/mL) and superoxide anion (IC500.56 to 0.88 mg/mL), followed by high reducing power (428-472 mgAA/g.DE) and inhibition of XOD (IC500.308-0.6261mg/mL). Antimutagenic activity was evaluated in reverse mutation assays with Escherichia coliWP2 oxyR mutant IC202 and deficient in the induction of antioxidant enzymes. The myrtle extracts strongly inhibited mutagenesis induced by t-BOOH, reaching 70% at the highest concentration applied. Antimicrobial activity was examined on eight different bacterial strains. Gram-positive bacteria, S. epidermis, S. aureusand M. flavus demonstrated the highest sensitivity towards extracts (MICs 4.5-9 mg/mL), but significantly lower towards essential oil (MIC 0.42-3.32 mg/mL).
黑山海岸线上的香桃木的生物活性
尽管许多研究都证明了桃金娘(桃金娘科)的生物医学潜力,但有关黑山桃金娘的数据却很少。本研究旨在评估桃金娘甲醇提取物的抗氧化、抗突变和抗菌活性。抗氧化活性是通过测量自由基清除活性、还原力和酶抑制作用来评估的。对 DPPH 自由基(2,2-二苯基-1-苦基肼)(IC501.69-2.25 mg/mL)和超氧阴离子(IC500.56-0.88 mg/mL)的清除活性最强,其次是高还原力(428-472 mgAA/g.DE)和对 XOD 的抑制(IC500.308-0.6261mg/mL)。用大肠杆菌 WP2 oxyR 突变体 IC202 和抗氧化酶诱导缺陷反向突变试验评估了桃金娘提取物的抗突变活性。桃金娘萃取物强烈抑制了 t-BOOH 诱导的突变,在使用的最高浓度下,抑制率达到 70%。对八种不同细菌菌株的抗菌活性进行了检测。革兰氏阳性菌、表皮葡萄球菌、金黄色葡萄球菌和黄曲霉菌对提取物的敏感性最高(MIC 4.5-9 mg/mL),但对精油的敏感性明显较低(MIC 0.42-3.32 mg/mL)。
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来源期刊
CiteScore
1.30
自引率
14.30%
发文量
49
审稿时长
6-12 weeks
期刊介绍: The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.
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