Encapsulated phenolic compounds: clinical efficacy of a novel delivery method

IF 7.3 2区 生物学 Q1 PLANT SCIENCES
Gulay Ozkan, Tuğçe Ceyhan, Gizem Çatalkaya, Logesh Rajan, Hammad Ullah, Maria Daglia, Esra Capanoglu
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引用次数: 0

Abstract

Encapsulation is a drug or food ingredient loaded-delivery system that entraps active components, protecting them from decomposition/degradation throughout the processing and storage stages and facilitates their delivery to the target tissue/organ, improving their bioactivities. The application of this technology is expanding gradually from pharmaceuticals to the food industry, since dietary bioactive ingredients, including polyphenols, are susceptible to environmental and/or gastrointestinal conditions. Polyphenols are the largest group of plants' secondary metabolites, with a wide range of biological effects. Literature data have indicated their potential in the prevention of several disorders and pathologies, ranging from simpler allergic conditions to more complex metabolic syndrome and cardiovascular and neurodegenerative diseases. Despite the promising health effects in preclinical studies, the clinical use of dietary polyphenols is still very limited due to their low bioaccessibility and/or bioavailability. Encapsulation can be successfully employed in the development of polyphenol-based functional foods, which may improve their bioaccessibility and/or bioavailability. Moreover, encapsulation can also aid in the targeted delivery of polyphenols and may prevent any possible adverse events. For the encapsulation of bioactive ingredients, several techniques are applied such as emulsion phase separation, emulsification/internal gelation, film formation, spray drying, spray-bed-drying, fluid-bed coating, spray-chilling, spray-cooling, and melt injection. The present review aims to throw light on the existing literature highlighting the possibility and clinical benefits of encapsulated polyphenols in health and disease. However, the clinical data is still very scarce and randomized clinical trials are needed before any conclusion is drawn.

Graphical abstract

Abstract Image

封装酚类化合物:一种新型给药方法的临床疗效
封装是一种药物或食品配料的负载输送系统,它能包裹活性成分,保护其在整个加工和储存阶段不被分解/降解,并促进其输送到目标组织/器官,提高其生物活性。由于包括多酚在内的膳食生物活性成分容易受到环境和/或胃肠道条件的影响,这项技术的应用正逐渐从制药业扩展到食品业。多酚是植物次生代谢物中最大的一类,具有广泛的生物效应。文献数据表明,多酚具有预防多种疾病的潜力,从简单的过敏症到复杂的代谢综合症、心血管疾病和神经退行性疾病,不一而足。尽管临床前研究表明膳食多酚具有良好的保健作用,但由于其生物可及性和/或生物利用率较低,因此在临床上的应用仍然非常有限。在开发以多酚为基础的功能食品时,可以成功地采用封装技术,从而提高其生物可及性和/或生物利用率。此外,封装还有助于有针对性地输送多酚,并可防止任何可能的不良事件。在封装生物活性成分时,可采用多种技术,如乳液相分离、乳化/内部凝胶化、成膜、喷雾干燥、喷雾干燥床、流化床涂层、喷雾冷却、喷雾冷却和熔融注射。本综述旨在对现有文献进行梳理,强调封装多酚对健康和疾病的可能性和临床益处。然而,临床数据仍然非常稀少,在得出结论之前需要进行随机临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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