A brief tale of two pioneering moments: Europe's first discovery of Tick-Borne Encephalitis (TBE) virus beyond the Soviet Union and the largest alimentary TBE outbreak in history

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases Pub Date : 2024-01-29 DOI:10.1016/j.ttbdis.2024.102314

Daniel Ruzek , Kristyna Kaucka

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引用次数: 0

Abstract

The emergence of tick-borne encephalitis (TBE) in Europe marked several significant milestones. The discovery of TBE in Czechoslovakia in 1948, with Gallia and Krejčí simultaneously isolating the TBE virus (TBEV) from human samples for the first time in Europe outside the Soviet Union, was pivotal. Subsequent TBEV isolation from ticks suggested the viral transmission via this vector. In 1951, the outbreak in Rožňava in Slovakia (Czechoslovakia) revealed an unexpected mode of transmission, unpasteurized milk from a local dairy, challenging existing understanding. Investigations exposed illicit practices of mixing cow's milk with goat's milk for economic gains. Laboratory research confirmed the outbreak was caused by TBEV, which was substantiated by serological analyses. This was the first and largest documented alimentary TBE outbreak in history. In this review, we delve into both published sources and unpublished archival data, offering a comprehensive understanding of these historic accomplishments and shedding light on these pivotal moments.

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两个开创性时刻的简短故事：欧洲首次在苏联以外地区发现蜱传脑炎（TBE）病毒，以及历史上最大规模的蜱传脑炎疫情爆发

蜱传脑炎（TBE）在欧洲的出现标志着几个重要的里程碑。1948 年，捷克斯洛伐克发现了蜱传脑炎，加利亚（Gallia）和克雷奇（Krejčí）同时从人类样本中分离出蜱传脑炎病毒（TBEV），这在苏联以外的欧洲地区尚属首次。随后从蜱虫身上分离出的 TBEV 表明病毒通过这种媒介传播。1951 年，斯洛伐克（捷克斯洛伐克）罗兹纳瓦疫情的爆发揭示了一种意想不到的传播方式，即来自当地奶制品厂的未经巴氏杀菌的牛奶，这对现有的认识提出了挑战。调查揭露了为了经济利益将牛奶与山羊奶混合的非法行为。实验室研究证实，疫情是由 TBEV 引起的，血清学分析也证实了这一点。这是历史上首次也是最大的一次有据可查的消化道结核病疫情。在这篇综述中，我们深入研究了已发表的资料和未发表的档案数据，全面了解了这些历史性成就，并揭示了这些关键时刻。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ticks and Tick-borne Diseases INFECTIOUS DISEASES-MICROBIOLOGY

CiteScore

6.90

自引率

12.50%

发文量

185

审稿时长

6-12 weeks

期刊介绍： Ticks and Tick-borne Diseases is an international, peer-reviewed scientific journal. It publishes original research papers, short communications, state-of-the-art mini-reviews, letters to the editor, clinical-case studies, announcements of pertinent international meetings, and editorials. The journal covers a broad spectrum and brings together various disciplines, for example, zoology, microbiology, molecular biology, genetics, mathematical modelling, veterinary and human medicine. Multidisciplinary approaches and the use of conventional and novel methods/methodologies (in the field and in the laboratory) are crucial for deeper understanding of the natural processes and human behaviour/activities that result in human or animal diseases and in economic effects of ticks and tick-borne pathogens. Such understanding is essential for management of tick populations and tick-borne diseases in an effective and environmentally acceptable manner.