Advantages of Cold Atmospheric Plasma Jet Generated by Positive Pulse Voltage in Anti-Cancer Therapy

IF 0.9 4区物理与天体物理 Q4 PHYSICS, FLUIDS & PLASMAS

Plasma Physics Reports Pub Date : 2024-01-27 DOI:10.1134/S1063780X2360130X

I. V. Schweigert, D. E. Zakrevsky, E. V. Milakhina, A. L. Aleksandrov, M. M. Biryukov, O. A. Koval

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Abstract

The intensity of the interaction between a helium cold atmospheric plasma jet (CAPJ) and a dielectric surface or animal skin is compared in experiment and numerical simulation. A cold plasma jet at atmospheric pressure is generated by a sinusoidal or positive pulsed voltage with different pulse durations in optimal modes. The impact effect is estimated on the basis of measured and calculated currents, line intensities in the CAPJ spectrum and temperature fields. The measured CAPJ characteristics show that the pulsed voltage for the CAPJ excitation is preferable compared to the sinusoidal mode. Varying the pulse duration of the periodic pulsed voltage makes it possible to obtain the maximum current and electric field strength at the surface within the permissible temperature in the contact area of the CAPJ with the skin of mice (<42°C). It is shown that the results of the CAPJ study obtained in physical experiments using a dielectric plate are applicable for tumor-bearing mice treatment.

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正脉冲电压产生的冷大气等离子体射流在抗癌治疗中的优势

摘要通过实验和数值模拟比较了氦冷等离子体射流（CAPJ）与介质表面或动物皮肤之间的相互作用强度。大气压下的冷等离子体射流是由正弦或正脉冲电压以不同的脉冲持续时间在最佳模式下产生的。根据测量和计算得出的电流、CAPJ 光谱中的线强度和温度场估算了冲击效应。测量的 CAPJ 特性表明，与正弦模式相比，脉冲电压更适合用于 CAPJ 激励。改变周期性脉冲电压的脉冲持续时间，可以在 CAPJ 与小鼠皮肤接触区域的允许温度（42°C）范围内获得表面的最大电流和电场强度。实验表明，使用电介质板在物理实验中获得的 CAPJ 研究结果适用于肿瘤小鼠的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasma Physics Reports 物理-物理：流体与等离子体

CiteScore

1.90

自引率

36.40%

发文量

104

审稿时长

4-8 weeks

期刊介绍： Plasma Physics Reports is a peer reviewed journal devoted to plasma physics. The journal covers the following topics: high-temperature plasma physics related to the problem of controlled nuclear fusion based on magnetic and inertial confinement; physics of cosmic plasma, including magnetosphere plasma, sun and stellar plasma, etc.; gas discharge plasma and plasma generated by laser and particle beams. The journal also publishes papers on such related topics as plasma electronics, generation of radiation in plasma, and plasma diagnostics. As well as other original communications, the journal publishes topical reviews and conference proceedings.