Occupational exposure to diesel exhausts and liver and pancreatic cancers: a systematic review and meta-analysis.

IF 7.7 1区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

European Journal of Epidemiology Pub Date : 2024-03-01 Epub Date: 2024-01-30 DOI:10.1007/s10654-024-01099-4

Michele Sassano, Giulia Collatuzzo, Federica Teglia, Paolo Boffetta

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引用次数: 0

Abstract

Background: Diesel exhaust (DE) is human carcinogen with sufficient evidence only for lung cancer. Systematic evidence on other cancer types is scarce, thus we aimed to systematically review current literature on the association between occupational DE exposure and risk of liver and pancreatic cancers.

Methods: We performed a systematic literature review to identify cohort studies on occupational DE exposure and risk of cancers other than lung. We computed pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) for liver and pancreatic cancers using DerSimonian and Laird random-effects model.

Results: Fifteen studies reporting results on pancreatic cancer and fourteen on liver cancer were included. We found a weakly increased risk of pancreatic cancer in workers exposed to DE (RR: 1.07, 95% CI: 1.00, 1.14), mainly driven by results on incidence (RR: 1.11, 95% CI: 1.02, 1.22). As for liver cancer, results were suggestive of a positive association (RR: 1.09; 95% CI: 0.99, 1.19), although a significant estimate was present in studies published before 2000 (RR: 1.41; 95% CI: 1.09, 1.82). We found no compelling evidence of publication bias.

Conclusions: Our findings suggest an association between occupational DE exposure and liver and pancreatic cancer. Further studies with detailed exposure assessment, environmental monitoring data, and appropriate control for confounders are warranted.

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职业暴露于柴油废气与肝癌和胰腺癌：系统回顾和荟萃分析。

背景：柴油废气（DE）是人类致癌物，仅有肺癌的充分证据。有关其他癌症类型的系统性证据很少，因此我们旨在系统地回顾目前有关职业性柴油废气暴露与肝癌和胰腺癌风险之间关系的文献：我们进行了一次系统性文献回顾，以确定有关职业性 DE 暴露与肺癌以外癌症风险的队列研究。我们使用 DerSimonian 和 Laird 随机效应模型计算了肝癌和胰腺癌的汇总相对风险 (RR) 和相应的 95% 置信区间 (CI)：共纳入了 15 项报告胰腺癌结果的研究和 14 项报告肝癌结果的研究。我们发现，暴露于 DE 的工人罹患胰腺癌的风险略有增加（RR：1.07，95% CI：1.00，1.14），这主要是由发病率（RR：1.11，95% CI：1.02，1.22）的结果引起的。至于肝癌，研究结果表明两者呈正相关（RR：1.09；95% CI：0.99, 1.19），但在 2000 年之前发表的研究中存在显著的估计值（RR：1.41；95% CI：1.09, 1.82）。我们没有发现令人信服的出版偏倚证据：我们的研究结果表明，职业性 DE 暴露与肝癌和胰腺癌之间存在关联。我们有必要通过详细的暴露评估、环境监测数据和对混杂因素的适当控制开展进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

21.40

自引率

1.50%

发文量

109

审稿时长

6-12 weeks

期刊介绍： The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.