Changes in Heart Rate Variability Parameters Following Radiofrequency Ablation in Patients with Atrial Fibrillation: A Systematic Review and Meta-Analysis.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Drugs and Therapy Pub Date : 2025-08-01 Epub Date: 2024-01-30 DOI:10.1007/s10557-024-07549-1

Mahsa Mansourian, Zahra Teimouri-Jervekani, Azam Soleimani, Rasool Nouri, Hamidreza Marateb, Marjan Mansourian

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引用次数: 0

Abstract

Purpose: Radiofrequency (RF) ablation is a prevalent treatment for atrial fibrillation (AF), targeting triggers within the pulmonary vein (PV) for elimination. This study evaluated heart rate variability (HRV) parameter changes at three intervals post-RF ablation: short-term (immediately to 1 month), medium-term (1 to 6 months), and long-term (6 months to 1 year). We compared two ablation techniques: circumferential PV isolation (CPVI) and segmental PV isolation (SPVI).

Methods: A thorough search of databases, including PubMed, Embase, Scopus, Web of Science, and Cochrane, in 2022 yielded 835 pertinent studies. After inclusion criteria were applied, 22 studies were analyzed.

Results: Results showed a marked decline in HRV parameters post-AF ablation, with LF/HF as an exception. These reductions persisted in short- and long-term evaluations up to a year post-procedure. Subgroup analysis revealed significant HRV declines, with distinct LF/HF values post-SPVI.

Conclusion: This meta-analysis suggests the potential of decreased HRV as an indicator of autonomic denervation, necessitating further exploration to optimize therapeutic strategies and enhance patient outcomes.

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心房颤动患者射频消融术后心率变异参数的变化：系统回顾与元分析》。

目的：射频（RF）消融术是治疗心房颤动（AF）的一种常用方法，其目标是消除肺静脉（PV）内的触发因素。本研究评估了射频消融术后三个时间段的心率变异性（HRV）参数变化：短期（即刻至 1 个月）、中期（1 至 6 个月）和长期（6 个月至 1 年）。我们比较了两种消融技术：环状 PV 隔离（CPVI）和节段性 PV 隔离（SPVI）：2022年，我们对PubMed、Embase、Scopus、Web of Science和Cochrane等数据库进行了全面检索，共获得835项相关研究。采用纳入标准后，对 22 项研究进行了分析：结果显示，AF消融术后心率变异参数明显下降，但低频/高频除外。这些下降在短期和长期评估中持续到术后一年。亚组分析显示心率变异显著下降，SPVI术后LF/HF值明显下降：这项荟萃分析表明，心率变异下降可能是自律神经失神经支配的一个指标，因此有必要进行进一步研究，以优化治疗策略，改善患者预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Drugs and Therapy 医学-心血管系统

CiteScore

8.30

自引率

0.00%

发文量

110

审稿时长

4.5 months

期刊介绍： Designed to objectively cover the process of bench to bedside development of cardiovascular drug, device and cell therapy, and to bring you the information you need most in a timely and useful format, Cardiovascular Drugs and Therapy takes a fresh and energetic look at advances in this dynamic field. Homing in on the most exciting work being done on new therapeutic agents, Cardiovascular Drugs and Therapy focusses on developments in atherosclerosis, hyperlipidemia, diabetes, ischemic syndromes and arrhythmias. The Journal is an authoritative source of current and relevant information that is indispensable for basic and clinical investigators aiming for novel, breakthrough research as well as for cardiologists seeking to best serve their patients. Providing you with a single, concise reference tool acknowledged to be among the finest in the world, Cardiovascular Drugs and Therapy is listed in Web of Science and PubMed/Medline among other abstracting and indexing services. The regular articles and frequent special topical issues equip you with an up-to-date source defined by the need for accurate information on an ever-evolving field. Cardiovascular Drugs and Therapy is a careful and accurate guide through the maze of new products and therapies which furnishes you with the details on cardiovascular pharmacology that you will refer to time and time again.