The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration

IF 2 3区 生物学 Q2 ANATOMY & MORPHOLOGY
Alejandro Castilla-Ibeas, Sofía Zdral, Kerby C. Oberg, Marian A. Ros
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引用次数: 0

Abstract

The limb anatomy displays well-defined dorsal and ventral compartments, housing extensor, and flexor muscles, which play a crucial role in facilitating limb locomotion and manipulation. Despite its importance, the study of limb dorsoventral patterning has been relatively neglected compared to the other two axes leaving many crucial questions about the genes and developmental processes implicated unanswered. This review offers a thorough overview of the current understanding of limb dorsoventral patterning, synthesizing classical literature with recent research. It covers the specification of dorsal fate in the limb mesoderm and its subsequent translation into dorsal morphologies—a process directed by the transcription factor Lmx1b. We also discuss the potential role of dorsoventral patterning in the evolution of paired appendages and delve into the involvement of LMX1B in Nail-Patella syndrome, discussing the molecular and genetic aspects underlying this condition. Finally, the potential role of dorsoventral polarity in digit tip regeneration, a prominent instance of multi-tissue regeneration in mammals is also considered. We anticipate that this review will renew interest in a process that is critical to limb function and evolutionary adaptations but has nonetheless been overlooked.

Abstract Image

肢体背腹轴:Lmx1b在发育、病理、进化和再生中的作用
肢体解剖学显示了明确的背腹腔,其中容纳了伸肌和屈肌,它们在促进肢体运动和操纵方面发挥着至关重要的作用。尽管肢体背腹侧模式化非常重要,但与其他两个轴相比,对肢体背腹侧模式化的研究相对被忽视,导致许多有关基因和发育过程的关键问题没有得到解答。这篇综述全面概述了目前对肢背腹形态的理解,综合了经典文献和最新研究。它涵盖了肢体中胚层背侧命运的规范及其随后转化为背侧形态的过程--这一过程由转录因子 Lmx1b 引导。我们还讨论了背腹模式化在成对附肢进化过程中的潜在作用,并深入探讨了 LMX1B 在钉状-帕泰拉综合征中的作用,讨论了这种病症的分子和遗传方面。最后,我们还探讨了背腹极性在指尖再生中的潜在作用,指尖再生是哺乳动物多组织再生的一个突出实例。我们希望这篇综述能重新引起人们对这一对肢体功能和进化适应至关重要但却一直被忽视的过程的兴趣。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Developmental Dynamics
Developmental Dynamics 生物-发育生物学
CiteScore
5.10
自引率
8.00%
发文量
116
审稿时长
3-8 weeks
期刊介绍: Developmental Dynamics, is an official publication of the American Association for Anatomy. This peer reviewed journal provides an international forum for publishing novel discoveries, using any model system, that advances our understanding of development, morphology, form and function, evolution, disease, stem cells, repair and regeneration.
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