Overlap syndrome of systemic sclerosis with antineutrophil cytoplasmic antibody-associated vasculitis according to 2022 ACR/EULAR criteria.

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Korean Journal of Internal Medicine Pub Date : 2024-05-01 Epub Date: 2024-01-29 DOI:10.3904/kjim.2023.189

Jang Woo Ha, Jung Yoon Pyo, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee

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引用次数: 0

Abstract

Background/aims: This study applied the 2022 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) criteria for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) to patients with systemic sclerosis (SSc) and investigated the frequency of overlap syndrome of SSc and AAV (SSc-AAV-OS).

Methods: Among the 232 patients diagnosed with SSc, 105 with signs suggestive of small- or medium-vessel vasculitis, which were defined as the present of interstitial lung disease (ILD), peripheral neuropathy, or suspected renal vasculitis, were included in this study and analyzed.

Results: Among the 105 SSc patients, the detection rate of ANCA was 19.0%. When the 2022 ACR/EULAR criteria were applied, the frequency of SSc-AAV-OS was 20.0%, which was much higher than 1.7% reported with previous criteria for AAV. ANCA positivity contributed to the reclassification of SSc-AAV-OS more than ANCA negativity in SSc patients with signs suggestive of small- or medium-vessel vasculitis.

Conclusion: The frequency of SSc-AAV-OS in SSc patients with signs suggestive of small- or medium-vessel vasculitis at diagnosis was 20.0%. Therefore, we suggest that physicians should perform ANCA tests in SSc patients exhibiting signs suggestive of small- or medium-vessel vasculitis and apply the new criteria for AAV.

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根据 2022 年 ACR/EULAR 标准，系统性硬化症与抗中性粒细胞胞浆抗体相关性血管炎重叠综合征。

背景/目的：这项研究将2022年美国风湿病学会（ACR）/欧洲风湿病学协会联盟（EULAR）的抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）标准应用于系统性硬化症（SSc）患者，并调查SSc与AAV（SSc-AAV-OS）重叠综合征的发生频率：方法：在232名确诊为SSc的患者中，有105名患者出现了提示中小血管炎的体征，即出现间质性肺病（ILD）、周围神经病变或疑似肾血管炎，本研究对这些患者进行了分析：在105名SSc患者中，ANCA的检出率为19.0%。当采用 2022 年 ACR/EULAR 标准时，SSc-AAV-OS 的发生率为 20.0%，远高于以往 AAV 标准下的 1.7%。在有中小血管炎体征的SSc患者中，ANCA阳性比ANCA阴性更有助于SSc-AAV-OS的重新分类：在确诊时有中小血管炎体征的 SSc 患者中，SSc-AAV-OS 的发生率为 20.0%。因此，我们建议医生对有中小血管炎体征的 SSc 患者进行 ANCA 检测，并应用 AAV 的新标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Korean Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

5.10

自引率

4.20%

发文量

129

审稿时长

20 weeks

期刊介绍： The Korean Journal of Internal Medicine is an international medical journal published in English by the Korean Association of Internal Medicine. The Journal publishes peer-reviewed original articles, reviews, and editorials on all aspects of medicine, including clinical investigations and basic research. Both human and experimental animal studies are welcome, as are new findings on the epidemiology, pathogenesis, diagnosis, and treatment of diseases. Case reports will be published only in exceptional circumstances, when they illustrate a rare occurrence of clinical importance. Letters to the editor are encouraged for specific comments on published articles and general viewpoints.