Evolution of the Major Components of Innate Immunity in Animals.

IF 2.1 3区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Molecular Evolution Pub Date : 2024-02-01 Epub Date: 2024-01-28 DOI:10.1007/s00239-024-10155-2

Rafael Cardoso Maciel Costa Silva, Fábio Mendonça Gomes

引用次数: 0

Abstract

Innate immunity is present in all animals. In this review, we explore the main conserved mechanisms of recognition and innate immune responses among animals. In this sense, we discuss the receptors, critical for binding to pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs); the downstream signaling proteins; and transcription factors that govern immune responses. We also highlight conserved inflammatory mediators that are induced after the recognition of DAMPs and PAMPs. At last, we discuss the mechanisms that are involved in the regulation and/or generation of reactive oxygen species (ROS), influencing immune responses, like heme-oxygenases (HOs).

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动物先天性免疫主要成分的进化。

先天性免疫存在于所有动物中。在这篇综述中，我们探讨了动物之间主要的保守识别机制和先天性免疫反应。在这个意义上，我们讨论了与病原体相关分子模式（PAMPs）或危险相关分子模式（DAMPs）结合的关键受体、下游信号蛋白以及支配免疫反应的转录因子。我们还强调了在识别 DAMP 和 PAMP 后诱导的保守炎症介质。最后，我们讨论了影响免疫反应的活性氧（ROS）的调节和/或生成机制，如血红素加氧酶（HOs）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Evolution 生物-进化生物学

CiteScore

5.50

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： Journal of Molecular Evolution covers experimental, computational, and theoretical work aimed at deciphering features of molecular evolution and the processes bearing on these features, from the initial formation of macromolecular systems through their evolution at the molecular level, the co-evolution of their functions in cellular and organismal systems, and their influence on organismal adaptation, speciation, and ecology. Topics addressed include the evolution of informational macromolecules and their relation to more complex levels of biological organization, including populations and taxa, as well as the molecular basis for the evolution of ecological interactions of species and the use of molecular data to infer fundamental processes in evolutionary ecology. This coverage accommodates such subfields as new genome sequences, comparative structural and functional genomics, population genetics, the molecular evolution of development, the evolution of gene regulation and gene interaction networks, and in vitro evolution of DNA and RNA, molecular evolutionary ecology, and the development of methods and theory that enable molecular evolutionary inference, including but not limited to, phylogenetic methods.