{"title":"Antihypertensive and ACE-2 Inhibitory Effects of <i>Daphne gnidium</i> in Rats.","authors":"Ismail Bouadid, Adil Qabouche, Mohamed Eddouks","doi":"10.2174/0118715257251651231212045407","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>The antihypertensive activity of <i>Daphne gnidium</i> was tested.</p><p><strong>Background: </strong><i>Daphne gnidium</i> (Thymelaeaceae) is used against hypertension.</p><p><strong>Objective: </strong>The antihypertensive effect of <i>Daphne gnidium</i> was evaluated in this study.</p><p><strong>Methods: </strong>The effect of <i>Daphne gnidium</i> aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.</p><p><strong>Results: </strong>DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptoractivated calcium channels (ROCCs) without affecting ACE-2.</p><p><strong>Conclusion: </strong>The aqueous extract of <i>Daphne gnidium</i> exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca<sup>2+</sup> entry.</p>","PeriodicalId":93924,"journal":{"name":"Cardiovascular & hematological agents in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular & hematological agents in medicinal chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0118715257251651231212045407","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Aims: The antihypertensive activity of Daphne gnidium was tested.
Background: Daphne gnidium (Thymelaeaceae) is used against hypertension.
Objective: The antihypertensive effect of Daphne gnidium was evaluated in this study.
Methods: The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.
Results: DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptoractivated calcium channels (ROCCs) without affecting ACE-2.
Conclusion: The aqueous extract of Daphne gnidium exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca2+ entry.
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