The role of estrogen metabolites in human ovarian function

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2024-01-24 DOI:10.1016/j.steroids.2024.109368

Soledad Henríquez , Maria Jose Valdivia , Monica Mainigi , Claudio Villarroel , Luis Velasquez , Jerome F. Strauss III , Luigi Devoto

引用次数: 0

Abstract

Estrogens produced by the ovary play diverse roles in controlling physiological changes in the function of the female reproductive system. Although estradiol acts through classical nuclear receptors, its metabolites (EMs) act by alternative pathways. It has been postulated that EMs act through paracrine-autocrine pathways to regulate key processes involved in normal follicular growth, corpus luteum (CL) development, function, and regression. The present review describes recent advances in understanding the role of EMs in human ovarian physiology during the menstrual cycle, including their role in anovulatory disorders and their action in other target tissues.

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雌激素代谢物在人体卵巢功能中的作用。

卵巢产生的雌激素在控制女性生殖系统功能的生理变化方面发挥着多种作用。虽然雌二醇通过传统的核受体发挥作用，但其代谢物（EMs）也通过其他途径发挥作用。据推测，EMs通过旁分泌-自分泌途径发挥作用，调节涉及正常卵泡生长、黄体（CL）发育、功能和衰退的关键过程。本综述介绍了在了解月经周期中EMs在人类卵巢生理中的作用方面取得的最新进展，包括它们在无排卵性疾病中的作用及其在其他靶组织中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.