Delirium Severity and Physical Function in Hospitalized Persons Living With Dementia: Moderation by Age, Sex, and Race.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2024-01-22 DOI:10.1097/WAD.0000000000000601

Ashley Kuzmik, Marie Boltz, Barbara Resnick, Rachel McPherson, Marleny Rodriguez, Brittany F Drazich, Elizabeth Galik

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引用次数: 0

Abstract

Objective: This study investigated whether demographic characteristics (age, sex, and race) moderated delirium severity as a predictor of physical function in hospitalized persons living with dementia.

Methods: The sample consisted of 351 patients enrolled in a randomized controlled trial (Function Focused Care for Acute Care Using the Evidence Integration Triangle). Preliminary analysis was conducted to assess the main effect, and multiple linear regression was used to examine the moderating effect of demographic characteristics between delirium severity and physical function.

Results: Both age and sex were found to have significant moderating effects on the relationship between delirium severity and physical function (β = 2.22; P = 0.02 and β = 1.34; P = 0.04, respectively). Older adults aged 85 years or older with higher levels of delirium severity reported lower levels of physical function compared with older adults aged 65 to 84 years. Males with higher levels of delirium severity reported lower levels of physical function compared with females. Race did not significantly moderate the association between delirium severity and physical function (β = 0.22; P = 0.90).

Conclusions: Our findings suggest that age and sex may have differential effects on physical function across different levels of delirium severity in hospitalized persons living with dementia.

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痴呆症住院患者的谵妄严重程度和身体功能：年龄、性别和种族的调节作用。

研究目的本研究调查了人口统计学特征（年龄、性别和种族）是否会调节谵妄严重程度，从而预测住院痴呆患者的身体功能：样本包括351名参加随机对照试验（使用证据整合三角的急性期功能集中护理）的患者。我们进行了初步分析以评估主效应，并使用多元线性回归来研究人口统计学特征在谵妄严重程度和身体功能之间的调节效应：结果：年龄和性别对谵妄严重程度与身体功能之间的关系均有显著的调节作用（分别为β = 2.22; P = 0.02和β = 1.34; P = 0.04）。与 65 至 84 岁的老年人相比，谵妄严重程度较高的 85 岁或以上老年人的身体功能水平较低。与女性相比，谵妄严重程度较高的男性报告的身体功能水平较低。种族并没有明显缓和谵妄严重程度与身体功能之间的关系（β = 0.22; P = 0.90）：我们的研究结果表明，年龄和性别可能会对不同谵妄严重程度的住院痴呆患者的身体功能产生不同的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.