Convection-enhanced Diffusion: A Novel Tactics to Crack the BBB.

Meenakshi Dhanawat, Garima, Kashish Wilson, Sumeet Gupta, Rishabh Chalotra, Nidhi Gupta
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Abstract

Although the brain is very accessible to nutrition and oxygen, it can be difficult to deliver medications to malignant brain tumours. To get around some of these issues and enable the use of therapeutic pharmacological substances that wouldn't typically cross the blood-brain barrier (BBB), convection-enhanced delivery (CED) has been developed. It is a cutting-edge strategy that gets beyond the blood-brain barrier and enables targeted drug administration to treat different neurological conditions such as brain tumours, Parkinson's disease, and epilepsy. Utilizing pressure gradients to spread the medicine across the target area is the main idea behind this diffusion mechanism. Through one to several catheters positioned stereotactically directly within the tumour mass, around the tumour, or in the cavity created by the resection, drugs are given. This method can be used in a variety of drug classes, including traditional chemotherapeutics and cutting-edge investigational targeted medications by using positive-pressure techniques. The drug delivery volume must be optimized for an effective infusion while minimizing backflow, which causes side effects and lowers therapeutic efficacy. Therefore, this technique provides a promising approach for treating disorders of the central nervous system (CNS).

对流增强扩散:破解 BBB 的新策略。
虽然大脑的营养和氧气非常容易获得,但要向恶性脑肿瘤输送药物却很困难。为了解决这些问题,并使用通常无法通过血脑屏障(BBB)的治疗药物,对流增强给药(CED)应运而生。这是一种超越血脑屏障、实现靶向给药的尖端策略,可用于治疗脑肿瘤、帕金森病和癫痫等不同的神经系统疾病。利用压力梯度将药物扩散到目标区域是这种扩散机制的主要理念。通过一根至数根导管,以立体定向方式将药物直接置于肿瘤内、肿瘤周围或切除后形成的空腔中。这种方法可用于多种药物类别,包括传统的化疗药物和利用正压技术研究的前沿靶向药物。必须优化给药量以实现有效输注,同时尽量减少回流,因为回流会导致副作用并降低疗效。因此,这种技术为治疗中枢神经系统(CNS)疾病提供了一种前景广阔的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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