Increased Pulmonary-Aortic Interspace in Fetal Right Aortic Arch: A Matched Case-Control Study.

IF 1.6 3区医学 Q3 OBSTETRICS & GYNECOLOGY

Fetal Diagnosis and Therapy Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI:10.1159/000536403

Bo B Bet, Agnes E van Steijn, Ingeborg H Linskens, Ingmar Knobbe, Elisabeth van Leeuwen, Eva Pajkrt, Sally-Ann Clur

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引用次数: 0

Abstract

Introduction: The prenatal detection rate of a right aortic arch (RAA) has increased with the implementation of the three-vessel view (3VV) to the second-trimester anomaly scan formed by the pulmonary artery (PA), aorta (Ao), and superior vena cava (SVC). We examined the value of measuring the distance between PA and Ao in the 3VV in cases with an RAA.

Methods: We conducted a case-control study in which fetuses with an isolated RAA were matched to 3 healthy controls. Using 3VV images, the distances between PA, Ao, and SVC were measured and the ratio between PA to Ao (PAAo) distance and Ao to SVC (AoSVC) distance was calculated.

Results: Fifty-four RAA cases and 162 matched controls were included. The mean absolute distance PAAo was 3.1 mm in cases and 1.8 mm in controls (p < 0.001), and the mean PAAo/AoSVC ratio was 2.9 and 1.4, respectively (p < 0.001). The ROC curve of PAAo/AoSVC ratio showed a cut-off point of 1.9 with sensitivity and specificity over 87% for the diagnosis of RAA.

Conclusions: The pulmonary-aortic interspace and the PAAo/AoSVC ratio were significantly larger for RAA cases as compared to controls. If an increased pulmonary-aortic interspace is observed, a PAAo/AoSVC of ≥1.9 can be helpful in the diagnosis of an RAA.

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胎儿右主动脉弓肺主动脉间隙增大：一项匹配病例对照研究。

导言：由肺动脉（PA）、主动脉（Ao）和上腔静脉（SVC）组成的三血管视图（3VV）在第二孕期异常扫描中的应用提高了右主动脉弓（RAA）的产前检出率。我们研究了在有 RAA 的病例中测量 3VV 中 PA 和 Ao 之间距离的价值：病例对照研究：将患有孤立 RAA 的胎儿与三名健康对照者进行配对。使用 3VV 图像测量 PA、Ao 和 SVC 之间的距离，并计算 PA 与 Ao 距离（PAAo）和 Ao 与 SVC 距离（AoSVC）之间的比率：结果：共纳入 54 例 RAA 病例和 162 例匹配对照。结果：共纳入 54 例 RAA 病例和 162 例匹配对照，病例 PAAo 的平均绝对距离为 3.1 毫米，对照组为 1.8 毫米（p 结论：与对照组相比，RAA 病例的肺主动脉间隔和 PAAo/AoSVC 比值明显增大。如果观察到肺主动脉间隔增大，PAAo/AoSVC≥1.9将有助于诊断RAA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fetal Diagnosis and Therapy 医学-妇产科学

CiteScore

4.70

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The first journal to focus on the fetus as a patient, ''Fetal Diagnosis and Therapy'' provides a wide range of biomedical specialists with a single source of reports encompassing the common discipline of fetal medicine.