Cow milk derived-fat inhibits the proliferation of liver cancer-cells

IF 2.3 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY
Meran Keshawa Ediriweera, Do Manh Cuong, Somi Kim Cho
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引用次数: 0

Abstract

Cow milk is a widely consumed liquid diet, and its fatty acid composition impacts its nutritional and biochemical properties. However, research on the anticancer efficacy of cow milk-derived fat in liver cancer cells is limited. This study investigated the antiproliferative and apoptotic effects of cow milk-derived fat in human hepatoma HepG2 cells. Additionally, the effects of cow milk-derived fat on cell cycle progression and Janus kinase (JAK)-2/signal transducer and activator of transcription (STAT)-3 signaling in HepG2 cells were assessed. Furthermore, the histone deacetylase inhibitory and 2,2-diphenyl-1-picrylhydrazyl radical scavenging potential of cow milk-derived fat were examined. The results demonstrate that cow milk-derived fat can exert antiproliferative and anticlonogenic effects and induce apoptosis in HepG2 cells dose-dependently. Furthermore, cow milk-derived fat induced cell cycle arrest, suppressed the levels of pJAK-2 and pSTAT-3, and inhibited the total histone deacetylase activity in HepG2 cells. The fatty acid profile of cow milk-derived fat revealed that palmitic, oleic, and linoleic acids were abundant as saturated, monounsaturated, and polyunsaturated fatty acids, respectively. Our findings provide a new scientific basis for the development of anticancer strategies that utilize cow milk-derived fat and its derivatives against liver cancer.

牛奶提取的脂肪能抑制肝癌细胞的增殖
牛奶是一种广泛食用的流质饮食,其脂肪酸组成影响着牛奶的营养和生化特性。然而,有关牛奶提取的脂肪对肝癌细胞的抗癌功效的研究还很有限。本研究调查了牛乳衍生脂肪在人肝癌 HepG2 细胞中的抗增殖和凋亡作用。此外,还评估了牛奶提取的脂肪对 HepG2 细胞的细胞周期进展和 Janus 激酶(JAK)-2/信号转导和转录激活因子(STAT)-3 信号转导的影响。此外,还检测了牛乳衍生脂肪的组蛋白去乙酰化酶抑制作用和 2,2-二苯基-1-苦基肼自由基清除潜力。结果表明,牛奶萃取脂肪具有抗增殖和抗克隆作用,并能诱导 HepG2 细胞发生剂量依赖性凋亡。此外,牛乳衍生脂肪还能诱导细胞周期停滞,抑制 pJAK-2 和 pSTAT-3 的水平,并抑制 HepG2 细胞中组蛋白去乙酰化酶的总活性。牛乳衍生脂肪的脂肪酸谱显示,棕榈酸、油酸和亚油酸分别作为饱和脂肪酸、单不饱和脂肪酸和多不饱和脂肪酸而含量丰富。我们的研究结果为利用牛乳衍生脂肪及其衍生物开发抗肝癌策略提供了新的科学依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Applied Biological Chemistry
Applied Biological Chemistry Chemistry-Organic Chemistry
CiteScore
5.40
自引率
6.20%
发文量
70
审稿时长
20 weeks
期刊介绍: Applied Biological Chemistry aims to promote the interchange and dissemination of scientific data among researchers in the field of agricultural and biological chemistry. The journal covers biochemistry and molecular biology, medical and biomaterial science, food science, and environmental science as applied to multidisciplinary agriculture.
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