Alcohol use-associated alterations in the circulating metabolite profile in the general population and in individuals with major depressive disorder

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol Pub Date : 2024-01-24 DOI:10.1016/j.alcohol.2024.01.005

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引用次数: 0

Abstract

Our aim was to evaluate whether alcohol use is associated with changes in the circulating metabolite profile similar to those present in persons with depression. If so, these findings could partially explain the link between alcohol use and depression. We applied a targeted liquid chromatography mass spectrometry method to evaluate correlates between concentrations of 86 circulating metabolites and self-reported alcohol use in a cohort of the non-depressed general population (GP) (n = 247) and a cohort of individuals with major depressive disorder (MDD) (n = 99). Alcohol use was associated with alterations in circulating concentrations of metabolites in both cohorts. Our main finding was that self-reported alcohol use was negatively correlated with serum concentrations of hippuric acid in the GP cohort. In the GP cohort, consumption of six or more doses per week was associated with low hippuric acid concentrations, similar to those observed in the MDD cohort, but in these individuals it was regardless of their level of alcohol use. Reduced serum concentrations of hippuric acid suggest that already-moderate alcohol use is associated with depression-like changes in the serum levels of metabolites associated with gut microbiota and liver function; this may be one possible molecular level link between alcohol use and depression.

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普通人群和重度抑郁障碍患者体内与饮酒相关的循环代谢物谱改变

我们的目的是评估饮酒是否与循环代谢物谱的变化有关，这些变化与抑郁症患者的情况相似。如果是，这些发现可以部分解释饮酒与抑郁症之间的联系。我们在非抑郁症普通人群（GP）（247 人）和重度抑郁障碍（MDD）患者（99 人）队列中采用靶向液相色谱质谱法评估了 86 种循环代谢物的浓度与自我报告的饮酒情况之间的相关性。在这两个队列中，饮酒都与代谢物循环浓度的变化有关。我们的主要发现是，在 GP 群体中，自我报告的饮酒情况与血清中的马尿酸浓度呈负相关。在GP队列中，每周饮酒六次或六次以上与马尿酸浓度低有关，这与在MDD队列中观察到的情况相似，但在这些人中，与饮酒程度无关。血清中马尿酸浓度的降低表明，适度饮酒会使血清中与肠道微生物群和肝功能相关的代谢物水平发生类似抑郁症的变化；这可能是饮酒与抑郁症之间的一种分子层面的联系。

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来源期刊

Alcohol 医学-毒理学

CiteScore

4.60

自引率

4.30%

发文量

审稿时长

15.6 weeks

期刊介绍： Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.