Establishment and characterisation of STAM4, a novel human adamantinomatous craniopharyngioma cell line, through human telomerase reverse transcriptase ectopic expression-mediated immortalisation

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Neuropathology and Applied Neurobiology Pub Date : 2024-01-21 DOI:10.1111/nan.12958

Chaohu Wang, Huarong Zhang, Rongrong Guo, Ya'nan Cao, Jun Pan, Haoying Yu, Xiaoyu Qiu, Jin Shi, Jun Fan, Songtao Qi, Yi Liu

引用次数: 0

Abstract

Adamantinomatous craniopharyngioma (ACP) is a rare benign intracranial tumour that occurs in the sellar region and likely originates from the embryonic craniopharyngeal epithelium (a remnant of the ectoderm, also known as Rathke's pouch). However, progress in ACP research has been slow due to the lack of ACP cell lines. Therefore, in this study, we established an immortalised ACP cell line.

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通过人类端粒酶逆转录酶异位表达介导的永生化，建立新型人类金刚瘤颅咽管瘤细胞系 STAM4 并确定其特征

金刚瘤性颅咽管瘤（ACP）是一种罕见的颅内良性肿瘤，好发于咽喉区，很可能起源于胚胎期的颅咽上皮（外胚层的残余，又称Rathke's pouch）。然而，由于缺乏 ACP 细胞系，ACP 研究进展缓慢。因此，在这项研究中，我们建立了一个永生化的 ACP 细胞系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropathology and Applied Neurobiology 医学-病理学

CiteScore

8.20

自引率

2.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Neuropathology and Applied Neurobiology is an international journal for the publication of original papers, both clinical and experimental, on problems and pathological processes in neuropathology and muscle disease. Established in 1974, this reputable and well respected journal is an international journal sponsored by the British Neuropathological Society, one of the world leading societies for Neuropathology, pioneering research and scientific endeavour with a global membership base. Additionally members of the British Neuropathological Society get 50% off the cost of print colour on acceptance of their article.