Novel rod-like carbon nanomaterials as near infrared-responsive drug delivery system for potential anticancer applications

IF 1.5 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Micro & Nano Letters Pub Date : 2024-01-23 DOI:10.1049/mna2.12190

Mengru Liu, Xiaoxue Du, Jingyi Liu, Guangshuo Wang, Jiajia Yang, Xueling Wang, Shuai Han, Zhongchao Huo

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Abstract

The combination of chemotherapy and photothermal therapy shows great potential in cancer treatment, and the carbon nanomaterials have been attracted great attention in biomedical technology. However, it is still a great challenge to design stimuli-responsive nano-carbon-based drug release systems with integrated functions. In this paper, rod-like carbon nanomaterials (RCNs) were prepared by the soft template hydrothermal method with glucose as raw materials, which were proved to have high photothermal efficiency (∼23.7%), as well as good biocompatibility and excellent drug-loading capacity. After that, RCNs were used to load doxorubicin (DOX) as DOX@RCNs for integrated photothermal/chemotherapy towards cancer, which demonstrated 52.2% higher cancer cell killing efficiency than that of RCNs under near infrared (NIR) irradiation in vitro. The authors’ approach provided a novel NIR-responsive nano platform for combined photothermal/chemotherapy towards cancer, which was considered to be of great potential in anticancer applications.

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新型棒状碳纳米材料作为近红外响应型给药系统在抗癌领域的潜在应用

化疗与光热疗法的结合在癌症治疗中显示出巨大的潜力，而碳纳米材料在生物医学技术中也引起了极大的关注。然而，如何设计出具有综合功能的刺激响应型纳米碳基药物释放系统仍然是一个巨大的挑战。本文以葡萄糖为原料，采用软模板水热法制备了棒状碳纳米材料（RCNs），证明其具有较高的光热效率（∼23.7%）、良好的生物相容性和优异的药物负载能力。随后，研究人员利用 RCNs 负载多柔比星（DOX），将其作为 DOX@RCNs 用于癌症的光热/化疗综合治疗，结果表明在体外近红外（NIR）照射下，DOX@RCNs 的癌细胞杀伤效率比 RCNs 高出 52.2%。作者的研究方法为癌症光热/化疗联合疗法提供了一种新型的近红外响应纳米平台，被认为在抗癌领域具有巨大的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Micro & Nano Letters 工程技术-材料科学：综合

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.8 months

期刊介绍： Micro & Nano Letters offers express online publication of short research papers containing the latest advances in miniature and ultraminiature structures and systems. With an average of six weeks to decision, and publication online in advance of each issue, Micro & Nano Letters offers a rapid route for the international dissemination of high quality research findings from both the micro and nano communities. Scope Micro & Nano Letters offers express online publication of short research papers containing the latest advances in micro and nano-scale science, engineering and technology, with at least one dimension ranging from micrometers to nanometers. Micro & Nano Letters offers readers high-quality original research from both the micro and nano communities, and the materials and devices communities. Bridging this gap between materials science and micro and nano-scale devices, Micro & Nano Letters addresses issues in the disciplines of engineering, physical, chemical, and biological science. It places particular emphasis on cross-disciplinary activities and applications. Typical topics include: Micro and nanostructures for the device communities MEMS and NEMS Modelling, simulation and realisation of micro and nanoscale structures, devices and systems, with comparisons to experimental data Synthesis and processing Micro and nano-photonics Molecular machines, circuits and self-assembly Organic and inorganic micro and nanostructures Micro and nano-fluidics