Gastric Helicobacter pylori infection does not contribute to extraoral halitosis and its eradication cannot achieve substantial reduction of halitosis

IF 4.3 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Helicobacter Pub Date : 2024-01-24 DOI:10.1111/hel.13047

Ying Chen, Xiao Xian Qian

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引用次数: 0

Abstract

Background

Some researchers have suggested that Helicobacter pylori (H. pylori) infection is attributed to extraoral halitosis. However, this viewpoint is increasingly challenged by clinical practice. This study was conducted with the aim of investigating changes of extraoral halitosis before and after H. pylori eradication.

Materials and Methods

Data of patients who had H. pylori infection and extraoral halitosis were retrospectively collected. H. pylori infection was diagnosed by positive ¹³C urea breath test (UBT). Extraoral halitosis was diagnosed by organoleptic score (OLS) ≥2 in nose breath. A 14-day bismuth-based quadruple therapy was administered for H. pylori eradication. Extraoral halitosis was examined before eradication (T1), on the first day after eradication (T2), 1 month after eradication (T3), and 3 months after eradication (T4). Eradication effect was checked by UBT at T3.

Results

A total of 100 patients were included. Eradication was successful in 74 out of 100 (74%) patients (success group) and failed in 26 out of 100 (26%) patients (failure group). 32 out of 74 (43.24%) patients in success group and 10 out of 26 (38.46%) patients in failure group had reduced halitosis at T2, 9 out of 74 (12.16%) patients in success group and 2 out 26 (7.69%) patients in failure group had relapsed halitosis at T3, and 23 out of 74 (31.08%) patients in success group and 8 out of 26 (30.77%) patients in failure group had relapsed halitosis at T4, without significant difference between groups at any time (p = 0.918, p = 0.808, and p = 0.808 respectively).

Conclusions

Helicobacter pylori infection does not contribute to extraoral halitosis. H. pylori eradication can achieve sustained but slight reduction of extraoral halitosis, probably due to its antibiotic effects on the gut microbiota rather than H. pylori.

查看原文本刊更多论文

胃幽门螺旋杆菌感染不会导致口外口臭，根除幽门螺旋杆菌也不会显著减轻口臭。

背景一些研究人员认为，幽门螺杆菌（H. pylori）感染是口外口臭的原因。然而，这种观点越来越受到临床实践的质疑。本研究旨在调查幽门螺杆菌根除前后口外口臭的变化。材料和方法回顾性收集了幽门螺杆菌感染和口外口臭患者的数据。幽门螺杆菌感染通过 13C 尿素呼气试验 (UBT) 阳性来诊断。口外口臭的诊断依据是鼻呼吸的感官评分（OLS）≥2。为根除幽门螺杆菌，患者接受了为期14天的铋剂四联疗法。分别在根除前（T1）、根除后第一天（T2）、根除后 1 个月（T3）和根除后 3 个月（T4）检查口外口臭。根除效果在 T3 时通过 UBT 进行检查。结果共纳入 100 名患者。100 名患者中有 74 人（74%）根除成功（成功组），26 人（26%）根除失败（失败组）。74 名成功组患者中有 32 人（43.24%）和 26 名失败组患者中有 10 人（38.46%）在 T2 期口臭减轻，74 名成功组患者中有 9 人（12.16%）和 26 名失败组患者中有 2 人（7.69%）在 T3 期口臭复发，74 名成功组患者中有 23 人（31.成功组中的 23 人（31.08%）和失败组中的 8 人（30.77%）在 T4 时口臭复发，组间在任何时间均无显著差异（分别为 p = 0.918、p = 0.808 和 p = 0.808）。结论幽门螺杆菌感染不会导致口外口臭。根除幽门螺杆菌可持续但轻微地减轻口外口臭，这可能是由于抗生素对肠道微生物群的影响，而不是幽门螺杆菌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Helicobacter 医学-微生物学

CiteScore

8.40

自引率

9.10%

发文量

审稿时长

2 months

期刊介绍： Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.