Seroprevalence of Helicobacter pylori infection among schoolchildren in southern Taiwan—A 20-year longitudinal follow-up

IF 4.3 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Helicobacter Pub Date : 2024-01-24 DOI:10.1111/hel.13049

Hsiao-Yu Lo, Yao-Jong Yang

{"title":"Seroprevalence of Helicobacter pylori infection among schoolchildren in southern Taiwan—A 20-year longitudinal follow-up","authors":"Hsiao-Yu Lo, Yao-Jong Yang","doi":"10.1111/hel.13049","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p><i>Helicobacter pylori</i> infection is primarily acquired in childhood and can lead to peptic ulcer diseases and gastric cancer. The prevalence of <i>H. pylori</i> infection varies widely in different countries. The aim of this study was to explore the change of pediatric <i>H. pylori</i> seroprevalence in the past two decades and to investigate the risk factors for pediatric <i>H. pylori</i> seropositivity in southern Taiwan.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>This study enrolled children aged 7–12 years in Tainan City in 2018 and compared the result with our previous data in 1998, 2005, and 2010. Parents of the participants were invited to fill out questionnaires, including information of personal history, family history of peptic ulcer diseases, annual household income, and source of drinking water. Blood samples were analyzed for anti-<i>H. pylori</i> IgG by enzyme-linked immunosorbent assay.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 391, 629, 618, and 488 elementary school students in Tainan City were enrolled in 1998, 2005, 2010, and 2018, respectively. There was a significant decline in <i>H. pylori</i> seroprevalence from 9.2% in 1998, 7.8% in 2005, 6.2% in 2010 to 4.7% in 2018 (<i>p</i> < 0.001). Neither gender difference nor age difference was found in <i>H. pylori</i> seropositivity in each year of enrollment. Low household income was significantly associated with pediatric <i>H. pylori</i> seropositivity.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The seroprevalence of <i>H. pylori</i> infection among elementary schoolchildren has remarkably declined in southern Taiwan in the past two decades. Low household income was a risk factor for pediatric <i>H. pylori</i> seropositivity.</p>\n </section>\n </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Helicobacter","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/hel.13049","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Helicobacter pylori infection is primarily acquired in childhood and can lead to peptic ulcer diseases and gastric cancer. The prevalence of H. pylori infection varies widely in different countries. The aim of this study was to explore the change of pediatric H. pylori seroprevalence in the past two decades and to investigate the risk factors for pediatric H. pylori seropositivity in southern Taiwan.

Materials and Methods

This study enrolled children aged 7–12 years in Tainan City in 2018 and compared the result with our previous data in 1998, 2005, and 2010. Parents of the participants were invited to fill out questionnaires, including information of personal history, family history of peptic ulcer diseases, annual household income, and source of drinking water. Blood samples were analyzed for anti-H. pylori IgG by enzyme-linked immunosorbent assay.

Results

A total of 391, 629, 618, and 488 elementary school students in Tainan City were enrolled in 1998, 2005, 2010, and 2018, respectively. There was a significant decline in H. pylori seroprevalence from 9.2% in 1998, 7.8% in 2005, 6.2% in 2010 to 4.7% in 2018 (p < 0.001). Neither gender difference nor age difference was found in H. pylori seropositivity in each year of enrollment. Low household income was significantly associated with pediatric H. pylori seropositivity.

Conclusions

The seroprevalence of H. pylori infection among elementary schoolchildren has remarkably declined in southern Taiwan in the past two decades. Low household income was a risk factor for pediatric H. pylori seropositivity.

查看原文本刊更多论文

台湾南部学童幽门螺旋杆菌感染的血清流行率--20 年纵向追踪调查

背景幽门螺杆菌感染主要发生在儿童时期，可导致消化性溃疡和胃癌。不同国家的幽门螺杆菌感染率差异很大。本研究旨在探讨过去二十年来台湾南部地区小儿幽门螺杆菌血清阳性率的变化，并调查小儿幽门螺杆菌血清阳性的风险因素。材料与方法本研究于2018年在台南市招募了7-12岁的儿童，并将结果与我们之前在1998年、2005年和2010年的数据进行了比较。受试者家长受邀填写调查问卷，内容包括个人病史、消化性溃疡家族病史、家庭年收入、饮用水来源等信息。血液样本通过酶联免疫吸附试验分析抗幽门螺杆菌 IgG。结果 1998年、2005年、2010年和2018年台南市分别共有391名、629名、618名和488名小学生参加了调查。幽门螺杆菌血清阳性率从 1998 年的 9.2%、2005 年的 7.8%、2010 年的 6.2% 降至 2018 年的 4.7%（p <0.001），降幅明显。在每一年的登记中，幽门螺杆菌血清阳性率均未发现性别差异或年龄差异。家庭收入低与小儿幽门螺杆菌血清阳性率明显相关。结论近二十年来，台湾南部小学生幽门螺杆菌血清阳性率明显下降。家庭收入低是小儿幽门螺杆菌血清阳性的一个风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Helicobacter 医学-微生物学

CiteScore

8.40

自引率

9.10%

发文量

审稿时长

2 months

期刊介绍： Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.