Dynamic vagal-mediated connectivity of cortical and subcortical central autonomic hubs predicts chronotropic response to submaximal exercise in healthy adults

IF 2.2 3区心理学 Q3 NEUROSCIENCES

Brain and Cognition Pub Date : 2024-01-23 DOI:10.1016/j.bandc.2024.106134

Maria Di Bello , Catie Chang , Roger McIntosh

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引用次数: 0

Abstract

Background

Despite accumulation of a substantial body of literature supporting the role of exercise on frontal lobe functioning, relatively less is understood of the interconnectivity of ventromedial prefrontal cortical (vmPFC) regions that underpin cardio-autonomic regulation predict cardiac chronotropic competence (CC) in response to sub-maximal exercise.

Methods

Eligibility of 161 adults (mean age = 48.6, SD = 18.3, 68% female) was based upon completion of resting state brain scan and sub-maximal bike test. Sliding window analysis of the resting state signal was conducted over 45-s windows, with 50% overlap, to assess how changes in photoplethysmography-derived HRV relate to vmPFC functional connectivity with the whole brain. CC was assessed based upon heart rate (HR) changes during submaximal exercise (HR change /HRmax (206–0.88 × age) – HRrest).

Results

During states of elevated HRV the vmPFC showed greater rsFC with an 83-voxel region of the hypothalamus (p < 0.001, uncorrected). Beta estimates of vmPFC connectivity extracted from a 6-mm sphere around this region emerged as the strongest predictor of CC (b = 0.283, p <.001) than age, BMI, and resting HRV F(8,144) = 6.30, p <.001.

Conclusion

Extensive glutamatergic innervation of the hypothalamus by the vmPFC allows for top-down control of the hypothalamus and its various autonomic efferents which facilitate chronotropic response during sub-maximal exercise.

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皮层和皮层下自律神经中枢的动态迷走神经介导连接可预测健康成年人对次极限运动的时变反应。

背景：尽管有大量文献支持运动对额叶功能的作用，但人们对支持心脏自主神经调节的腹内侧前额叶皮层（vmPFC）区域的相互联系了解相对较少，而这些区域可预测心脏对次最大限度运动的顺时针能力（CC）：161名成年人（平均年龄为48.6岁，SD=18.3，68%为女性）在完成静息状态脑扫描和亚极限自行车测试后获得了研究资格。静息状态信号的滑动窗口分析在 45 秒的窗口内进行，重叠率为 50%，以评估光电血压衍生 HRV 的变化与 vmPFC 与整个大脑功能连接的关系。CC是根据亚极限运动时的心率（HR）变化（HR变化/HRmax (206-0.88 × 年龄) - HRrest）进行评估的：结果表明：在心率变异升高的状态下，vmPFC 与下丘脑的 83 个象素区域显示出更大的 rsFC（p 结论：在心率变异升高的状态下，vmPFC 与下丘脑的 83 个象素区域显示出更大的 rsFC：vmPFC对下丘脑的广泛谷氨酸能神经支配可对下丘脑及其各种自律神经传出进行自上而下的控制，从而促进亚极限运动期间的促时差反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain and Cognition 医学-神经科学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Brain and Cognition is a forum for the integration of the neurosciences and cognitive sciences. B&C publishes peer-reviewed research articles, theoretical papers, case histories that address important theoretical issues, and historical articles into the interaction between cognitive function and brain processes. The focus is on rigorous studies of an empirical or theoretical nature and which make an original contribution to our knowledge about the involvement of the nervous system in cognition. Coverage includes, but is not limited to memory, learning, emotion, perception, movement, music or praxis in relationship to brain structure or function. Published articles will typically address issues relating some aspect of cognitive function to its neurological substrates with clear theoretical import, formulating new hypotheses or refuting previously established hypotheses. Clinical papers are welcome if they raise issues of theoretical importance or concern and shed light on the interaction between brain function and cognitive function. We welcome review articles that clearly contribute a new perspective or integration, beyond summarizing the literature in the field; authors of review articles should make explicit where the contribution lies. We also welcome proposals for special issues on aspects of the relation between cognition and the structure and function of the nervous system. Such proposals can be made directly to the Editor-in-Chief from individuals interested in being guest editors for such collections.