Executive function measures of participants with mild cognitive impairment: Systematic review and meta-analysis of event-related potential studies

IF 2.5 3区心理学 Q3 NEUROSCIENCES

International Journal of Psychophysiology Pub Date : 2024-01-23 DOI:10.1016/j.ijpsycho.2023.112295

Jiajun Che , Nan Cheng , Bicong Jiang , Yanli Liu , Haihong Liu , Yutong Li , Haining Liu

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引用次数: 0

Abstract

Objective

Objective measurements of executive functions using event-related potential (ERP) may be used as markers for differentiating healthy controls (HC) from patients with mild cognitive impairment (MCI). ERP is non-invasive, cost-effective, and affordable. Older adults with MCI demonstrate deteriorated executive function, serving as a potentially valid neurophysiological marker for identifying MCI. We aimed to review published ERP studies on executive function in older adults with MCI and summarize the performance differences by component between healthy older adults and older adults with MCI.

Methods

Eight electronic databases (Web of Science, PubMed, ScienceDirect, American Psychological Association PsycNet, Cochrane Library, Scopus, Embase, and Ovid) were searched for the study. Articles published from January 1 to December 31, 2022, were considered for this review. A random-effects meta-analysis and between-study heterogeneity analysis were conducted using Comprehensive Meta-Analysis V3.0 software.

Results

We identified 7829 articles of which 28 met the full inclusion criteria and were included in the systematic review and analyses. Our pooled analysis suggested that participants with MCI can be differentiated from HC by significant P200, P300, and N200 latencies. The P100 and P300 amplitudes were significantly smaller in participants with MCI when compared with those in the HCs, and the patients with MCI showed increased N200 amplitudes. Our findings provide new insights into potential electrophysiological biomarkers for diagnosing MCI.

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轻度认知障碍患者的执行功能测量：事件相关电位研究的系统回顾和荟萃分析。

利用事件相关电位（ERP）对执行功能进行客观测量，可作为区分健康对照组（HC）和轻度认知障碍（MCI）患者的标志。ERP是一种非侵入性、成本效益高且经济实惠的方法。患有 MCI 的老年人会表现出执行功能退化，这可能是识别 MCI 的有效神经生理学标记。我们的目的是回顾已发表的有关 MCI 老年人执行功能的 ERP 研究，并总结健康老年人和 MCI 老年人在各部分表现上的差异。本研究检索了八个电子数据库（Web of Science、PubMed、ScienceDirect、美国心理学会 PsycNet、Cochrane Library、Scopus、Embase 和 Ovid）。本综述考虑了 2022 年 1 月 1 日至 12 月 31 日发表的文章。我们使用 Comprehensive Meta-Analysis V3.0 软件进行了随机效应荟萃分析和研究间异质性分析。我们确定了 7829 篇文章，其中 28 篇符合全部纳入标准，并纳入了系统综述和分析。我们的汇总分析表明，MCI 患者可通过显著的 P200、P300 和 N200 潜伏期与 HC 患者区分开来。与 HC 患者相比，MCI 患者的 P100 和 P300 波幅明显较小，而 MCI 患者的 N200 波幅则有所增加。我们的研究结果为诊断 MCI 的潜在电生理生物标记物提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Psychophysiology 医学-神经科学

CiteScore

5.40

自引率

10.00%

发文量

177

审稿时长

3-8 weeks

期刊介绍： The International Journal of Psychophysiology is the official journal of the International Organization of Psychophysiology, and provides a respected forum for the publication of high quality original contributions on all aspects of psychophysiology. The journal is interdisciplinary and aims to integrate the neurosciences and behavioral sciences. Empirical, theoretical, and review articles are encouraged in the following areas: • Cerebral psychophysiology: including functional brain mapping and neuroimaging with Event-Related Potentials (ERPs), Positron Emission Tomography (PET), Functional Magnetic Resonance Imaging (fMRI) and Electroencephalographic studies. • Autonomic functions: including bilateral electrodermal activity, pupillometry and blood volume changes. • Cardiovascular Psychophysiology:including studies of blood pressure, cardiac functioning and respiration. • Somatic psychophysiology: including muscle activity, eye movements and eye blinks.