A comprehensive review of antimalarial medicinal plants used by Tanzanians.

IF 3.9 3区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Pharmaceutical Biology Pub Date : 2024-12-01 Epub Date: 2024-01-25 DOI:10.1080/13880209.2024.2305453
David Sylvester Kacholi
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引用次数: 0

Abstract

Context: Tanzania has rich medicinal plant (MP) resources, and most rural inhabitants rely on traditional healing practices for their primary healthcare needs. However, available research evidence on antimalarial MPs is highly fragmented in the country.

Objective: This systematic review compiles ethnomedicinal research evidence on MPs used by Tanzanians as antimalarials.

Materials and methods: A systematic web search was conducted using various electronic databases and grey materials to gather relevant information on antimalarial MPs utilized by Tanzanians. The review was per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The data were collected from 25 articles, and MS Excel software was used to analyse relevant ethnobotanical information using descriptive statistics.

Results: A total of 227 MPs belonging to 67 botanical families and 180 genera were identified. Fabaceae (15.9%) is the most frequently utilized family. The ethnobotanical recipes analysis indicated leaves (40%) and trees (44%) are the preferred MPs part and life form, respectively. Decoctions (67%) are the dominant preparation method of remedies. Of the recorded MPs, 25.9% have been scientifically investigated for antimalarial activities with positive results. However, 74.1% of MPs have no scientific records on antimalarial activities, but they could be potential sources of remedies.

Conclusions: The study discloses a wealth of antimalarial MPs possessed by Tanzanians and suggests a need for research to authenticate the healing potential of antimalarial compounds from the unstudied MPs. Additionally, it indicates that some of the presented MPs are potential sources for developing safe, effective and affordable antimalarial drugs.

对坦桑尼亚人使用的抗疟疾药用植物的全面回顾。
背景:坦桑尼亚拥有丰富的药用植物(MP)资源,大多数农村居民依赖传统疗法来满足其初级保健需求。然而,该国关于抗疟药物的现有研究证据非常零散:本系统综述汇编了有关坦桑尼亚人用作抗疟药物的 MPs 的民族医药研究证据:利用各种电子数据库和灰色资料进行了系统性网络搜索,以收集有关坦桑尼亚人使用的抗疟药物的相关信息。审查符合系统审查和元分析首选报告项目(PRISMA)声明。从 25 篇文章中收集了数据,并使用 MS Excel 软件通过描述性统计分析了相关民族植物学信息:结果:共发现 227 种 MPs,隶属于 67 个植物科和 180 个属。豆科(15.9%)是最常用的植物科。民族植物学配方分析表明,叶(40%)和树(44%)分别是首选的 MPs 部分和生命形式。煎煮法(67%)是主要的药方制备方法。在已记录的 MPs 中,25.9% 的 MPs 已进行过抗疟活性的科学研究,结果呈阳性。然而,74.1%的中药没有抗疟活性的科学记录,但它们可能是潜在的药方来源:这项研究揭示了坦桑尼亚人所拥有的丰富的抗疟药物,并表明有必要开展研究,从未曾研究过的药物中鉴定抗疟化合物的治疗潜力。此外,研究还表明,其中一些主要成分是开发安全、有效和负担得起的抗疟药物的潜在来源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmaceutical Biology
Pharmaceutical Biology 医学-药学
CiteScore
6.70
自引率
2.60%
发文量
191
审稿时长
1 months
期刊介绍: Pharmaceutical Biology will publish manuscripts describing the discovery, methods for discovery, description, analysis characterization, and production/isolation (including sources and surveys) of biologically-active chemicals or other substances, drugs, pharmaceutical products, or preparations utilized in systems of traditional medicine. Topics may generally encompass any facet of natural product research related to pharmaceutical biology. Papers dealing with agents or topics related to natural product drugs are also appropriate (e.g., semi-synthetic derivatives). Manuscripts will be published as reviews, perspectives, regular research articles, and short communications. The primary criteria for acceptance and publication are scientific rigor and potential to advance the field.
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