Percutaneous microwave ablation versus sclerotherapy for large hepatic hemangioma: a multi-center cohort study.

IF 3 3区 医学 Q2 ONCOLOGY
International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI:10.1080/02656736.2023.2285705
Qian Cai, Tong-Gang Qian, Qi-Yu Zhao, Shun-You Feng, Qiao Yang, Yan-Chun Luo, Yu-Qing Dai, Ping Liang, Xiao-Ling Yu, Fang-Yi Liu, Zhi-Yu Han, Qiao-Wei Du, Xin Li, Jie Yu
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Abstract

Objective: The study aimed to compare the effectiveness and safety of ultrasound-guided microwave ablation (MWA) and percutaneous sclerotherapy (PS) for the treatment of large hepatic hemangioma (LHH).

Methods: This retrospective study included 96 patients who underwent MWA (n = 54) and PS (n = 42) as first-line treatment for LHH in three tertiary hospitals from January 2016 to December 2021. Primary outcomes were technique efficacy rate (volume reduction rate [VRR] > 50% at 12 months), symptom relief rate at 12 months and local tumor progression (LTP). Secondary outcomes included procedure time, major complications, treatment sessions, cost and one-, two-, three-year VRR.

Results: During a median follow-up of 36 months, the MWA group showed a higher technique efficacy rate (100% vs. 90.4%, p = .018) and symptom relief rate (100% vs. 80%, p = .123) than the PS group. The MWA group had fewer treatment sessions, higher one-, two- and three-year VRR, lower LTP rate (all p < .05), longer procedure time and higher treatment costs than the PS group (both p < .001). MWA shared a comparable major complications rate (1.8% vs. 2.4%, p = .432) with PS. After multivariate analysis, the lesion's heterogeneity and maximum diameter >8.1 cm were independent risk factors for LTP (all p < .05). In the PS group, lesions with a cumulative dose of bleomycin > 0.115 mg/cm3 had a lower risk of LTP (p = .006).

Conclusions: Both MWA and PS treatments for large hepatic hemangioma are safe and effective, with MWA being superior in terms of efficacy.

经皮微波消融与硬化剂注射治疗大肝脏血管瘤:一项多中心队列研究。
研究目的该研究旨在比较超声引导下微波消融术(MWA)和经皮硬化剂注射术(PS)治疗肝大血管瘤(LHH)的有效性和安全性:这项回顾性研究纳入了2016年1月至2021年12月期间在三家三级医院接受微波消融术(54例)和经皮硬化剂注射术(42例)作为LHH一线治疗的96例患者。主要结果为技术有效率(12个月时体积缩小率[VRR] >50%)、12个月时症状缓解率和局部肿瘤进展(LTP)。次要结果包括手术时间、主要并发症、治疗次数、费用以及一年、两年、三年的体积缩小率:结果:在中位随访 36 个月期间,MWA 组的技术有效率(100% 对 90.4%,p = .018)和症状缓解率(100% 对 80%,p = .123)均高于 PS 组。与 PS 相比,MWA 组的治疗次数更少,一年、两年和三年的 VRR 更高,LTP 率更低(所有 p p = .432)。经过多变量分析,病变的异质性和最大直径大于 8.1 厘米是 LTP 的独立危险因素(所有 p 0.115 mg/cm3 的 LTP 风险较低(p = .006):结论:MWA和PS治疗巨大肝血管瘤均安全有效,其中MWA在疗效方面更胜一筹。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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