Analysis of Factors Associated with Constipation in the Population with Obesity: Evidence from the National Health and Nutrition Examination Survey.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Obesity Facts Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI:10.1159/000536318

Yongping Hong, Xingxing Chen, Junping Liu

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引用次数: 0

Abstract

Introduction: Obesity and constipation are both global problems, but the factors associated with constipation in individuals with obesity are currently understudied. The aim of our study was to explore the factors associated with constipation in people with obesity.

Methods: From three cycles of the National Health and Nutrition Examination Survey (NHANES) 2005-2010, data from 14,048 persons aged ≥20 years were collected. Variables included demographics, lifestyle, comorbidities, and dietary data. Multiple logistic regression analysis was used to calculate adjusted prevalence odds ratio (OR) and assess the relationship between different variables and constipation in population with obesity.

Results: Using stool consistency definition, multivariate analysis revealed that education ≥12th grade (OR: 0.456; 95% CI: 0.300, 0.694; p = 0.00024), hypertension (OR: 0.505; 95% CI: 0.334, 0.763; p = 0.00119), polypharmacy (OR: 1.669; 95% CI: 1.104, 2.521; p = 0.01507), high cholesterol (OR: 0.400; 95% CI: 0.213, 0.750; p = 0.00430), and high dietary fiber (OR: 0.454; 95% CI: 0.245, 0.841; p = 0.01206) were substantially linked with constipation in the population with obesity. For constipation defined using stool frequency, multivariate regression analysis show constipation in people with obesity had a significant association with the female sex (OR: 2.684; 95% CI: 1.379, 5.223; p = 0.00366 multivariate), Mexican American (OR: 0.142; 95% CI, 0.033, 0.616; p = 0.00914 multivariate), hypertension (OR: 0.569; 95% CI: 0.324, 0.998; p = 0.04916), depression (OR: 2.280; 95% CI: 1.240, 4.195; p = 0.00803), occasional/often milk consumption (OR: 0.473; 95% CI: 0.286, 0.782; p = 0.00356), medium energy (OR: 0.318; 95% CI: 0.118, 0.856; p = 0.02338), polypharmacy (OR: 1.939; 95% CI: 1.115, 3.373; p = 0.01907), and medium moisture (OR: 0.534; 95% CI: 0.285, 0.999; p = 0.04959). In nonobese people, constipation was significantly associated with the female sex and high moisture but not with hypertension and polypharmacy.

Conclusion: This study suggests that the population with obesity has many factors that affect constipation such as hypertension, polypharmacy, cholesterol, dietary fiber, depression, and so on, of which hypertension and polypharmacy were significant associated with constipation, regardless of definitions of constipation. Notably, hypertension might be associated with a reduced risk of constipation in people with obesity.

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肥胖人群便秘的相关因素分析：来自全国健康与营养调查的证据。

导言：肥胖症和便秘都是全球性问题，但目前对肥胖症患者便秘的相关因素研究不足。我们的研究旨在探讨肥胖症患者便秘的相关因素：方法：从 2005-2010 年三个周期的美国国家健康与营养调查（NHANES）中收集了 14048 名年龄≥20 岁者的数据。变量包括人口统计学、生活方式、合并症和饮食数据。采用多元逻辑回归分析计算调整后的患病率比值（OR），并评估不同变量与肥胖人群便秘之间的关系：使用粪便一致性定义，多变量分析显示，教育程度≥12 年级（OR，0.456；95%CI，0.300，0.694，p=0.00024）、高血压（OR，0.505；95%CI，0.334，0.763，p=0.00119）、多药（OR，1.669；95%CI，1.104，2.521，p=0.01507）、高胆固醇（OR，0.400；95%CI，0.213，0.750，p= 0.00430）和高膳食纤维（OR，0.454；95%CI，0.245，0.841，p=0.01206）与肥胖人群的便秘密切相关。对于用粪便频率定义的便秘，多变量回归分析表明，肥胖人群的便秘与女性（OR，2.684；95%CI，1.379，5.223，多变量 p=0.00366）、墨西哥裔美国人（OR，0.142；95%CI，0.033，0.616，多变量 p=0.00914）、高血压（OR，0.569；95%CI，0.324，0.998，P=0.04916）、抑郁（OR，2.280；95%CI，1.240，4.195，P=0.00803）、偶尔/经常喝牛奶（OR，0.473；95%CI，0.286，0.782，P=0.00356）、中等能量（OR，0.318；95%CI，0.118，0.856，p=0.02338）、多药（OR，1.939；95%CI，1.115，3.373，p=0.01907）和中等水分（OR，0.534；95%CI，0.285，0.999，p=0.04959）。在非肥胖人群中，便秘与女性和高水分显著相关，但与高血压和多重药物治疗无关：本研究表明，肥胖人群中有许多影响便秘的因素，如高血压、多种药物、胆固醇、膳食纤维、抑郁等，其中高血压和多种药物与便秘显著相关，而与便秘的定义无关。值得注意的是，高血压可能与肥胖症患者便秘风险的降低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Facts 医学-内分泌学与代谢

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.