Liver and ovarian toxicities boosted by bisphenol and gamma radiation in female albino rats.

Asmaa A Hassan, Sherein S Abdelgayed, Somaya Z Mansour
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Abstract

Bisphenol A (BPA), a carbon-based synthetic polymer compound, was newly classified as an environmental toxicant and an endocrine-disrupting chemical leading to abnormalities in cell proliferation, apoptosis, or migration that contributes to cancer development and progression. This study aims to evaluate the effect of the elevation of γ- radiation dose and BPA on the liver and ovaries of female rats. In this study, eighty female albino rats (130-150 g) were used in this work. Rats in this experiment received BPA in ethanol (50 mg/kg b. wt.) for 30 days, day after day, and in the irradiated groups, animals were administered BPA and then exposed to γ- radiation in doses (2, 4, and 6 Gy) one shot dose. Several members of the cytochrome family were examined. Exposure to γ-radiation and BPA showed an increase in cytochrome P450 and b5 fold change. Further, BPA and γ-radiation activate α and β estrogen receptors and also downregulate aromatase (CYT19) fold change. The current results also revealed that BPA and/or γ-radiation regulate the protein expression of the PI3K/Akt signaling pathway. The steroidogenic acute regulatory protein (StAR) appeared to be targeted by BPA and γ-radiation and its relative expression was elevated significantly by raising the γ-radiation dose. In conclusion, exposure to BPA, an endocrine-disrupting chemical, leads to marked toxicity. Additionally, toxicity is heightened by increasing the γ-radiation dose, either alone or in combination with BPA.

双酚和伽马射线对雌性白化大鼠肝脏和卵巢的毒性增强
双酚 A(BPA)是一种碳基合成高分子化合物,新近被列为环境有毒物质和干扰内分泌的化学物质,会导致细胞增殖、凋亡或迁移异常,从而导致癌症的发生和发展。本研究旨在评估γ 辐射剂量和双酚 A 升高对雌性大鼠肝脏和卵巢的影响。本研究使用了 80 只白化雌性大鼠(体重 130-150 克)。在辐照组中,给动物注射双酚 A 后,再以 2、4 和 6 Gy 剂量一次性照射γ-射线。对细胞色素家族的几个成员进行了检测。暴露于γ射线和双酚 A 显示细胞色素 P450 和 b5 的折叠变化增加。此外,双酚 A 和 γ 辐射激活了 α 和 β 雌激素受体,并下调了芳香化酶(CYT19)的折叠变化。目前的研究结果还显示,双酚 A 和/或γ-辐射调节 PI3K/Akt 信号通路的蛋白表达。类固醇生成急性调节蛋白(StAR)似乎是双酚A和γ-辐射的靶标,其相对表达量随着γ-辐射剂量的增加而显著升高。总之,暴露于双酚 A 这种干扰内分泌的化学物质会导致明显的毒性。此外,增加γ-辐射剂量(无论是单独使用还是与双酚A一起使用)会增强毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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