Navigating complexities of racial disparities in Alzheimer disease biomarkers

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2024-01-23 DOI:10.1038/s41582-024-00930-6

Maria C. Carrillo, Simin Mahinrad

引用次数: 0

Abstract

An analysis based on datasets from four studies of memory and ageing reveals differences in the relationship of cognition with cerebrospinal fluid, but not imaging, biomarkers for Alzheimer disease between self-identified Black and White participants. These findings highlight the importance of precision medicine to address Alzheimer disease disparities across diverse populations. A study now reveals that CSF, but not imaging, biomarkers for Alzheimer disease show weaker correlation to cognitive measures in Black people than in White people. The findings offer insights into Alzheimer disease biomarker utility across racially diverse groups.

查看原文本刊更多论文

驾驭阿尔茨海默病生物标志物种族差异的复杂性。

一项基于四项记忆和老化研究数据集的分析表明，自我认同的黑人和白人参与者在认知与脑脊液生物标志物的关系上存在差异，但与阿尔茨海默病的成像生物标志物无关。这些发现凸显了精准医学对解决不同人群阿尔茨海默病差异的重要性。现在的一项研究显示，与白人相比，黑人的阿尔茨海默病脑脊液生物标志物与认知指标的相关性较弱，而成像生物标志物则不然。这些发现为阿尔茨海默病生物标志物在不同种族群体中的应用提供了启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.