Association between Brachial Flow-Mediated Dilation and Calcium Score in Patients with Symptomatic CAD.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Preventive Medicine Pub Date : 2023-11-30 eCollection Date: 2023-01-01 DOI:10.4103/ijpvm.ijpvm_143_22

Faezeh Tabesh, Mozhgan Amooali, Reihaneh Zavar, Amirreza Sajjadieh Khajouei

{"title":"Association between Brachial Flow-Mediated Dilation and Calcium Score in Patients with Symptomatic CAD.","authors":"Faezeh Tabesh, Mozhgan Amooali, Reihaneh Zavar, Amirreza Sajjadieh Khajouei","doi":"10.4103/ijpvm.ijpvm_143_22","DOIUrl":null,"url":null,"abstract":"Background: Endothelial function plays an important role in the protection of vessels from atherosclerosis. Detection of endothelial dysfunction by non-invasive methods (flow-mediated dilation) and its association with other imaging modalities (calcium score in coronary computed tomography [CT] angiography) is still controversial. In this study, we aim to investigate the association between endothelial function evaluated by flow-mediated dilation (FMD) and calcium score evaluated by coronary CT.Methods: In this cross-sectional study, 124 patients with known coronary artery disease (CAD, positive calcium score) were enrolled. FMD as an indicator of endothelial function was evaluated in these participants. FMD less than 7.1%was considered abnormal. Correlation between calcium score and severity of calcification(calcium score above 100 considered as the cutoff point of the high score) and glow-mediated dilation was obtained using the linear regression model.Results: The association between calcium score and FMD was strongly significant (P < 0.001). Among individuals with low calcium scores, only 15 (18.1%) had abnormal FMD findings, but the majority of individuals with high calcium scores (95.1%) had abnormal FMD findings.Conclusions: Our findings provide strong evidence of association between FMD, a marker of vascular endothelial dysfunction, and intensity of coronary atherosclerosis, as assessed by the calcium score on the CCTA.","PeriodicalId":14342,"journal":{"name":"International Journal of Preventive Medicine","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803685/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Preventive Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijpvm.ijpvm_143_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Endothelial function plays an important role in the protection of vessels from atherosclerosis. Detection of endothelial dysfunction by non-invasive methods (flow-mediated dilation) and its association with other imaging modalities (calcium score in coronary computed tomography [CT] angiography) is still controversial. In this study, we aim to investigate the association between endothelial function evaluated by flow-mediated dilation (FMD) and calcium score evaluated by coronary CT.

Methods: In this cross-sectional study, 124 patients with known coronary artery disease (CAD, positive calcium score) were enrolled. FMD as an indicator of endothelial function was evaluated in these participants. FMD less than 7.1%was considered abnormal. Correlation between calcium score and severity of calcification(calcium score above 100 considered as the cutoff point of the high score) and glow-mediated dilation was obtained using the linear regression model.

Results: The association between calcium score and FMD was strongly significant (P < 0.001). Among individuals with low calcium scores, only 15 (18.1%) had abnormal FMD findings, but the majority of individuals with high calcium scores (95.1%) had abnormal FMD findings.

Conclusions: Our findings provide strong evidence of association between FMD, a marker of vascular endothelial dysfunction, and intensity of coronary atherosclerosis, as assessed by the calcium score on the CCTA.

查看原文本刊更多论文

有症状的 CAD 患者肱动脉血流介导的扩张与钙评分之间的关系

背景：内皮功能在保护血管免于动脉粥样硬化方面发挥着重要作用。通过非侵入性方法（血流介导的扩张）检测内皮功能障碍及其与其他成像模式（冠状动脉计算机断层扫描血管造影的钙化评分）之间的关联仍存在争议。本研究旨在探讨血流介导扩张（FMD）评估的内皮功能与冠状动脉 CT 评估的钙化评分之间的关联：在这项横断面研究中，我们招募了 124 名已知患有冠状动脉疾病（CAD，钙化评分呈阳性）的患者。这些参与者的 FMD 作为内皮功能的指标接受了评估。FMD低于7.1%被视为异常。使用线性回归模型得出了钙化评分和钙化严重程度（钙化评分超过 100 分为高分的临界点）与辉光介导的扩张之间的相关性：结果：钙化评分与 FMD 之间的关系非常显著（P < 0.001）。在低钙评分者中，只有 15 人（18.1%）的 FMD 结果异常，但大多数高钙评分者（95.1%）的 FMD 结果异常：我们的研究结果提供了强有力的证据，证明血管内皮功能障碍的标志物 FMD 与冠状动脉粥样硬化的强度（由 CCTA 上的钙评分评估）之间存在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

3.20

自引率

4.80%

发文量

107

期刊介绍： International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.