Ectopia Lentis: Clinical profiles in a large cohort of children from a Tertiary Eye Care network in India

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-19 DOI:10.4103/tjo.tjo-d-23-00150

M. Bhate, A. Das, R. Kekunnaya, V. Sachdeva, Muralidhar Ramappa, V. Warkad, Debasmita Majhi

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Abstract

To study the clinical presentations, visual, and refractive profiles of children with congenital ectopia lentis in a large cohort of patients from a tertiary eye care network in India. A retrospective review of electronic medical records from December 2012 to December 2020 was conducted. Two hundred and ninety-seven consecutive children ≤18 years of age at presentation were identified and analyzed for demographic details, patient distribution, lens subluxation, visual, and refractive profiles before and after the interventions. Five hundred and ninety-four eyes of 297 (male 56%; n = 166) patients were analyzed. The mean age at presentation was 8.74 ± 3.89. Best-corrected visual acuity (BCVA) at presentation ranged from 0.3 logMAR to 3.5 logMAR; (Snellen: 6/9 – close to face [CF]) (mean 0.89 ± 0.68). High myopia (n = 201; 33.83%) and mild astigmatism (n = 340; 57.23%) were more frequent. Temporal (n = 108; 18.18%) subluxation was most common followed by superior. Lensectomy with limited vitrectomy was performed in 243 eyes of 127 patients (40.90%). Median preoperative BCVA was 1.0 (range: 0.3–3.5 logMAR; 20/40 - CF). Median postoperative BCVA was 0.5 logMAR (6/18) in the pseudophakic group and 0.6 logMAR (6/24) in the aphakic group. Spherical equivalent in myopic children reduced from −12.06 ± 6.84D to −1.57D (−0.25D to − 5.5D) in the pseudophakic group and +9.3D (+5.5D to 15.5D) in the aphakic group. This study is a large cohort of children presenting with ectopia lentis. Following intervention, an improvement in the median BCVA and refractive correction was noted in the entire cohort.

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眼睑外翻：来自印度三级眼科医疗网络的一大批儿童的临床特征

目的：研究印度一家三级眼科医疗网络的庞大患者队列中患有先天性眼睑外翻的儿童的临床表现、视力和屈光情况。该研究对 2012 年 12 月至 2020 年 12 月期间的电子病历进行了回顾性分析。共确定了297名就诊时年龄小于18岁的连续儿童，并对干预前后的人口统计学细节、患者分布、晶状体脱位、视力和屈光情况进行了分析。共对 297 名患者（男性占 56%；n = 166）的 594 只眼睛进行了分析。患者的平均年龄为（8.74 ± 3.89）岁。发病时的最佳矫正视力（BCVA）从 0.3 logMAR 到 3.5 logMAR 不等；（斯奈伦视力表：6/9 - 近视 [CF]）（平均值为 0.89 ± 0.68）。高度近视（n = 201；33.83%）和轻度散光（n = 340；57.23%）更为常见。颞侧（n = 108；18.18%）脱位最常见，其次是上侧。127名患者（40.90%）的243只眼睛接受了有限玻璃体切除术。术前 BCVA 中位数为 1.0（范围：0.3-3.5 logMAR；20/40 - CF）。假性近视组术后 BCVA 中位数为 0.5 logMAR (6/18)，无晶体眼组术后 BCVA 中位数为 0.6 logMAR (6/24)。假性近视组近视儿童的球面等值从-12.06 ± 6.84D降至-1.57D（-0.25D至-5.5D），无晶体眼组的球面等值为+9.3D（+5.5D至15.5D）。这项研究是一项大规模的眼睑外翻患儿队列研究。干预后，整个队列的BCVA和屈光矫正中位数均有所改善。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.