Occupational exposure to pesticides deregulates systemic cortisol levels in women with breast cancer and correlates with poor prognosis features

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-22 DOI:10.1590/1414-431X2023e13060

J.J. Jumes, H.S. Jaques, M.F. Dalla Vecchia, M.O. Ferreira, J.F.G. Orrutéa, M.G. Machado, M.F. Mezoni, R.G.S. da Silva, R.F. Almeida, D. Rech, A. Kawassaki, C. Panis

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Abstract

Pesticides have been pointed out as hormone disruptors and may significantly affect the prognosis of hormone-dependent diseases such as breast cancer (BC). Here, we investigated the impact of occupational pesticide exposure on systemic cortisol levels in female rural workers diagnosed with BC. Occupational exposure was assessed by interviews with a standardized questionnaire. Plasma samples (112 from pesticide-exposed women and 77 from unexposed women) were collected in the afternoon, outside the physiological cortisol peak, and analyzed by a chemiluminescent paramagnetic immunoassay for the quantitative determination of cortisol levels in serum and plasma. The results from both groups were categorized according to patients' clinicopathological and exposure data. BC pesticide-exposed women presented higher levels of cortisol than the unexposed. Higher cortisol levels were also detected in the exposed group with more aggressive disease (triple-negative BC), with tumors over 2 cm, with lymph node metastases, and with high risk of disease recurrence and death. These findings demonstrated that there is an association between pesticide exposure and BC that affected cortisol levels and correlated to poor disease prognosis.

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职业性接触杀虫剂会降低乳腺癌女性患者的全身皮质醇水平，并与不良预后特征有关

农药被指出是激素干扰物，可能会严重影响激素依赖性疾病（如乳腺癌）的预后。在此，我们研究了职业杀虫剂暴露对确诊为乳腺癌的农村女工全身皮质醇水平的影响。通过标准化问卷的访谈评估了职业暴露情况。血浆样本（112 份来自接触过农药的妇女，77 份来自未接触过农药的妇女）在下午生理皮质醇峰值外采集，并通过化学发光顺磁免疫分析法定量测定血清和血浆中的皮质醇水平。根据患者的临床病理和接触数据对两组结果进行了分类。接触过 BC 杀虫剂的妇女的皮质醇水平高于未接触者。皮质醇水平较高的人群还包括：疾病更具侵袭性（三阴性 BC）、肿瘤超过 2 厘米、淋巴结转移、疾病复发和死亡风险高的暴露人群。这些研究结果表明，接触杀虫剂与乳腺癌之间存在关联，这种关联会影响皮质醇水平，并与疾病的不良预后相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.