A role for the gut microbiota in immune checkpoint inhibitor-induced colitis

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-01-23 DOI:10.1038/s41575-024-00897-1

Katrina Ray

引用次数: 0

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肠道微生物群在免疫检查点抑制剂诱发的结肠炎中的作用

新研究表明，细胞毒性T淋巴细胞蛋白4（CTLA4）阻断诱导的结肠炎取决于肠道微生物群，后者通过Fcγ受体诱导CD4+ T细胞的活化和调节性T（Treg）细胞的消耗。重要的是，缺乏Fc结构域的抗CTLA纳米抗体能在小鼠模型中激发抗肿瘤免疫，而不会诱发结肠炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.

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