Changes of synaptic vesicles in three-dimensional synapse models by treatment with umbelliferone in scopolamine-induced hippocampal injury model

Q3 Immunology and Microbiology

Applied Microscopy Pub Date : 2024-01-23 DOI:10.1186/s42649-024-00095-y

Ga-Young Choi, Eunyoung Moon, Hyosung Choi, Hee-Seok Kweon

引用次数: 0

Abstract

The neuroprotective effects of umbelliferone (UMB) were visualized in three-dimensional (3D) images on vesicle density changes of organotypic hippocampal slice tissues (OHSCs) induced by scopolamine by high voltage electron microscopy. Observations revealed that the number of vesicles decreased in OHSCs induced by scopolamine, and UMB was found to inhibit scopolamine-induced reduction in vesicles, resulting in an increase in vesicle count. These 3D models provide valuable insight for understanding the increase of synapse vesicles in hippocampal tissues treated with UMB.

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在东莨菪碱诱导的海马损伤模型中使用伞形酮治疗三维突触模型中突触小泡的变化

高压电子显微镜通过三维图像观察了伞形酮（UMB）对东莨菪碱诱导的器官型海马片组织（OHSCs）囊泡密度变化的神经保护作用。观察结果显示，东莨菪碱诱导的OHSCs中囊泡数量减少，而UMB能抑制东莨菪碱诱导的囊泡减少，从而使囊泡数量增加。这些三维模型为了解用UMB处理的海马组织中突触小泡的增加提供了宝贵的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Microscopy Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： Applied Microscopy is a peer-reviewed journal sponsored by the Korean Society of Microscopy. The journal covers all the interdisciplinary fields of technological developments in new microscopy methods and instrumentation and their applications to biological or materials science for determining structure and chemistry. ISSN: 22875123, 22874445.