The role of hormones in ILC2-driven allergic airway inflammation

IF 4.1 4区 医学 Q2 IMMUNOLOGY
Zhongling Dai, Zhande Gong, Cui Wang, WeiXiang Long, Duo Liu, Haijun Zhang, Aihua Lei
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引用次数: 0

Abstract

Group 2 innate lymphoid cells (ILC2s) are a type of innate immune cells that produce a large amount of IL-5 and IL-13 and two cytokines that are crucial for various processes such as allergic airway inflammation, tissue repair and tissue homeostasis. It is known that damaged epithelial-derived alarmins, such as IL-33, IL-25 and thymic stromal lymphopoietin (TSLP), are the predominant ILC2 activators that mediate the production of type 2 cytokines. In recent years, abundant studies have found that many factors can regulate ILC2 development and function. Hormones synthesized by the body's endocrine glands or cells play an important role in immune response. Notably, ILC2s express hormone receptors and their proliferation and function can be modulated by multiple hormones during allergic airway inflammation. Here, we summarize the effects of multiple hormones on ILC2-driven allergic airway inflammation and discuss the underlying mechanisms and potential therapeutic significance.

Abstract Image

激素在 ILC2 驱动的过敏性气道炎症中的作用
第 2 组先天性淋巴细胞(ILC2s)是一种先天性免疫细胞,能产生大量 IL-5 和 IL-13 这两种细胞因子,它们对过敏性气道炎症、组织修复和组织稳态等各种过程至关重要。众所周知,受损上皮衍生的 alarmins,如 IL-33、IL-25 和胸腺基质淋巴细胞生成素(TSLP),是介导 2 型细胞因子产生的主要 ILC2 激活因子。近年来,大量研究发现,许多因素都能调节 ILC2 的发育和功能。人体内分泌腺或细胞合成的激素在免疫反应中发挥着重要作用。值得注意的是,ILC2 表达激素受体,在过敏性气道炎症过程中,它们的增殖和功能可受到多种激素的调节。在此,我们总结了多种激素对 ILC2 驱动的过敏性气道炎症的影响,并讨论了其潜在的机制和治疗意义。
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来源期刊
CiteScore
7.70
自引率
5.40%
发文量
109
审稿时长
1 months
期刊介绍: This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.
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