Post-occlusive reactive hyperemia in habituated caffeine users: Effects of abstaining versus consuming typical doses.

Clinical hemorheology and microcirculation Pub Date : 2024-01-01 DOI:10.3233/CH-232036

Matthew A Chatlaong, Daphney M Stanford, William M Miller, Chance J Davidson, Matthew B Jessee

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Abstract

Background: Post-occlusive reactive hyperemia (PORH) typically requires caffeine abstinence. For habitual users, it is unknown if abstinence affects PORH.

Objective: Compare PORH after habitual users consume or abstain from caffeine.

Methods: On separate visits (within-subject), PORH was measured in 30 participants without abstinence from typical caffeine doses (CAFF) and with abstinence (ABS). Measurements included baseline and peak hyperemic velocity, tissue saturation index slopes during ischemia (Slope 1) and following cuff deflation (Slope 2), resting arterial occlusion pressure (AOP), heart rate (HR), systolic (SBP), and diastolic (DBP) blood pressure. All variables were compared using Bayesian paired t-tests. BF10 = likelihood of alternative vs null. Results are mean±SD.

Results: Comparing baseline velocity (cm/s) between CAFF (9.3±4.8) and ABS (7.5±4.9) yielded anecdotal evidence (BF10 = 1.0). Peak hyperemic velocity (cm/s) was similar (CAFF = 77.3±16.7; ABS = 77.6±19.0, BF10 = 0.20). For slopes (TSI% /s), CAFF Slope 1 = -0.11±0.04 and Slope 2 = 1.9±0.46 were similar (both BF10≤0.20) to ABS Slope 1 = -0.12±0.03 and Slope 2 = 1.8±0.42. SBP and DBP (mmHg) were both similar (CAFF SBP = 116.0±9.8, DBP = 69.6±5.8; ABS SBP = 115.5±10.7, DBP = 69.5±5.4; both BF10≤0.22). Comparing AOP (mmHg) (CAFF = 146.6±15.0; ABS = 143.0±16.4) yielded anecdotal evidence (BF10 = 0.46). HR (bpm) was similar (CAFF = 66.5±12.3; ABS = 66.9±13.0; BF10 = 0.20).

Conclusions: In habitual users, consuming or abstaining from typical caffeine doses does not appear to affect post-occlusive reactive hyperemia.

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习惯性咖啡因使用者的闭塞后反应性充血：禁食与摄入典型剂量的影响。

背景：闭塞后反应性充血（PORH）通常需要禁用咖啡因。对于习惯性使用者来说，戒断咖啡因是否会影响 PORH 尚不清楚：比较习惯性使用者摄入或禁用咖啡因后的 PORH：方法：对 30 名未禁用典型咖啡因剂量（CAFF）和禁用咖啡因剂量（ABS）的参与者进行单独访问（受试者内），测量其 PORH。测量项目包括基线和峰值充血速度、缺血时（斜率 1）和袖带放气后（斜率 2）的组织饱和度指数斜率、静息动脉闭塞压（AOP）、心率（HR）、收缩压（SBP）和舒张压（DBP）。所有变量均采用贝叶斯配对 t 检验进行比较。BF10 = 备选与否的可能性。结果为平均值±SD：结果：比较 CAFF（9.3±4.8）和 ABS（7.5±4.9）的基线速度（厘米/秒）可得出轶事证据（BF10 = 1.0）。峰值充血速度（厘米/秒）相似（CAFF = 77.3±16.7；ABS = 77.6±19.0，BF10 = 0.20）。斜率（TSI% /s）方面，CAFF 斜率 1 = -0.11±0.04 和斜率 2 = 1.9±0.46 与 ABS 斜率 1 = -0.12±0.03 和斜率 2 = 1.8±0.42 相似（BF10 均≤0.20）。SBP和DBP（mmHg）均相似（CAFF SBP = 116.0±9.8，DBP = 69.6±5.8；ABS SBP = 115.5±10.7，DBP = 69.5±5.4；BF10均≤0.22）。比较 AOP（mmHg）（CAFF = 146.6±15.0；ABS = 143.0±16.4）得出的结论（BF10 = 0.46）。心率（bpm）相似（CAFF = 66.5±12.3；ABS = 66.9±13.0；BF10 = 0.20）：结论：对于习惯性使用者，摄入或不摄入典型剂量的咖啡因似乎不会影响闭塞后反应性充血。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical hemorheology and microcirculation

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