Mortality in patients with schizophrenia in Japan.

IF 3.6 2区医学 Q1 PSYCHIATRY

Social Psychiatry and Psychiatric Epidemiology Pub Date : 2024-10-01 Epub Date: 2024-01-20 DOI:10.1007/s00127-023-02592-z

Nobuyuki Nomura, Fuminari Misawa, Yasuo Fujii, Hiroyoshi Takeuchi

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引用次数: 0

Abstract

Purpose: Patients with schizophrenia have a higher mortality risk than the general population. However, no recent studies have investigated mortality in patients with schizophrenia in Japan. Therefore, we conducted a retrospective study to evaluate excess mortality and risk factors for mortality in patients with schizophrenia in Japan.

Methods: We included patients diagnosed with schizophrenia or schizoaffective disorder at Yamanashi Prefectural Kita Hospital between January 1, 2013, and December 31, 2017. Standardized mortality ratios (SMRs) were used to compare mortality rates between patients with schizophrenia and the general population. Logistic regression analysis was performed to estimate risk factors associated with mortality.

Results: Of the 1,699 patients with schizophrenia (893 men and 806 women), 104 (55 men and 49 women) died during the study period. The all-cause SMR (95% confidence interval [CI]) was 2.18 (1.76-2.60); the natural- and unnatural-cause SMRs were 2.06 (1.62-2.50) and 5.07 (2.85-7.30), respectively. Men (adjusted odds ratio [OR] = 2.24, 95% CI = 1.10-4.56), age (adjusted OR = 1.12, 95% CI = 1.09-1.16), and barbiturate use (adjusted OR = 8.17, 95% CI = 2.07-32.32) were associated with the risk of mortality.

Conclusion: The mortality rate remains high in patients with schizophrenia in Japan. Further studies are needed to evaluate mortality trends in this population.

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日本精神分裂症患者的死亡率。

目的：精神分裂症患者的死亡风险高于普通人群。然而，最近没有研究调查过日本精神分裂症患者的死亡率。因此，我们进行了一项回顾性研究，以评估日本精神分裂症患者的超额死亡率和死亡风险因素：我们纳入了 2013 年 1 月 1 日至 2017 年 12 月 31 日期间在山梨县北医院确诊为精神分裂症或分裂情感障碍的患者。采用标准化死亡率（SMR）来比较精神分裂症患者与普通人群的死亡率。对与死亡率相关的风险因素进行了逻辑回归分析：在 1699 名精神分裂症患者（男性 893 人，女性 806 人）中，有 104 人（男性 55 人，女性 49 人）在研究期间死亡。全因 SMR（95% 置信区间 [CI]）为 2.18（1.76-2.60）；自然和非自然原因 SMR 分别为 2.06（1.62-2.50）和 5.07（2.85-7.30）。男性（调整后比值比 [OR] = 2.24，95% CI = 1.10-4.56）、年龄（调整后比值比 [OR] = 1.12，95% CI = 1.09-1.16）和使用巴比妥类药物（调整后比值比 [OR] = 8.17，95% CI = 2.07-32.32）与死亡风险有关：结论：日本精神分裂症患者的死亡率仍然很高。结论：日本精神分裂症患者的死亡率仍然很高，需要进一步研究来评估这一人群的死亡率趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Social Psychiatry and Psychiatric Epidemiology 医学-精神病学

CiteScore

8.50

自引率

2.30%

发文量

184

审稿时长

3-6 weeks

期刊介绍： Social Psychiatry and Psychiatric Epidemiology is intended to provide a medium for the prompt publication of scientific contributions concerned with all aspects of the epidemiology of psychiatric disorders - social, biological and genetic. In addition, the journal has a particular focus on the effects of social conditions upon behaviour and the relationship between psychiatric disorders and the social environment. Contributions may be of a clinical nature provided they relate to social issues, or they may deal with specialised investigations in the fields of social psychology, sociology, anthropology, epidemiology, health service research, health economies or public mental health. We will publish papers on cross-cultural and trans-cultural themes. We do not publish case studies or small case series. While we will publish studies of reliability and validity of new instruments of interest to our readership, we will not publish articles reporting on the performance of established instruments in translation. Both original work and review articles may be submitted.