Comparative Evaluation of Medicinal Plant Extracts and Antimicrobial Magistrals.

IF 1.5 4区医学 Q4 MICROBIOLOGY

New Microbiologica Pub Date : 2024-01-01

Hager Muftah, Berrin Özçelik, Ozlem Oyardi, Didem Deliorman Orhan

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Abstract

The in vitro antimicrobial activity of the active ingredient in antimicrobial magistral drug formulations and plant extracts used in folk medicine were investigated comparatively. Borax, sulfur colloid, hydrogen peroxide, benzoic acid, rivanol, brilliant green and plant extracts as active ingredients, namely: Helianthus tuberosus tuber-H2O (aqueous extract), Cydonia oblonga leaves-H2O, Allium porrum whole plant-H2O, Cistus laurifolius leaves-EtOH, Solanum muricalum-H2O, and Fumaria cilicica leaves-EtOH were studied to determine their antimicrobial activity against different bacteria and fungi (S. pyogenes, S. aureus, S. epidermidis, E. faecalis, K. pneumonia, H. influenza, P. aeruginosa, A. baumannii, E. coli, Candida albicans, C. tropicalis, C. parapsilosis, C. krusei) by using the microdilution method. The active ingredients and plant extracts showed different activities as MIC between 1->128 μg/mL. Brilliant green and rivanol as active ingredients had MIC values of 1 μg/mL against all tested microorganisms. C. oblonga leaves-H2O as well as C. laurifolius leaves-EtOH as plant extracts were indicated as having the highest antimicrobial effect in MIC value of 16 μg/ml against A. baumannii and S. pyogenes, respectively. On the other hand, F. cilicica leaves-EtOH and C. laurifolius leaves-EtOH showed the highest antifungal activity (MIC; 16 μg/mL).

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药用植物提取物和抗菌药的比较评估

比较研究了抗菌药物配方中的活性成分和民间医药中使用的植物提取物的体外抗菌活性。作为活性成分的硼砂、硫胶体、过氧化氢、苯甲酸、利凡诺、亮绿和植物提取物，即这些植物提取物包括：Helianthus tuberosus tuber-H2O（水提取物）、Cydonia oblonga leaves-H2O、Allium porrum whole plant-H2O、Cistus laurifolius leaves-EtOH、Solanum muricalum-H2O，以及 Fumaria cilicica leaves-EtOH。化脓性葡萄球菌、金黄色葡萄球菌、表皮葡萄球菌、粪大肠杆菌、肺炎双球菌、流感嗜血杆菌、铜绿假单胞菌、鲍曼不动杆菌、大肠杆菌、白色念珠菌、热带念珠菌、副丝状念珠菌、克鲁塞念珠菌）的抗菌活性。活性成分和植物提取物显示出不同的活性，其 MIC 值介于 1->128 μg/mL 之间。作为活性成分的亮绿和利凡诺对所有受试微生物的 MIC 值均为 1 μg/mL。植物萃取物 C. oblonga leaves-H2O 和 C. laurifolius leaves-EtOH 对鲍曼尼氏菌和化脓性链球菌的抗菌效果最高，MIC 值分别为 16 μg/ml。另一方面，F. cilicica 叶-EtOH 和 C. laurifolius 叶-EtOH 显示出最高的抗真菌活性（MIC；16 μg/ml）。

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来源期刊

New Microbiologica 生物-微生物学

CiteScore

2.20

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The publication, diffusion and furtherance of research and study on all aspects of basic and clinical Microbiology and related fields are the chief aims of the journal.