Role of sex in immune response and epigenetic mechanisms.

IF 4.2 2区生物学 Q1 GENETICS & HEREDITY

Epigenetics & Chromatin Pub Date : 2024-01-22 DOI:10.1186/s13072-024-00525-x

Sombodhi Bhattacharya, Debasmita Sadhukhan, Radha Saraswathy

引用次数: 0

Abstract

The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex chromosomes and hormonal differences. Epigenetic mechanisms such as X chromosome inactivation, mosaicism, skewing, and dimorphism in X chromosome genes and Y chromosome regulatory genes create a sex-based variance in the immune response between males and females. This leads to differential susceptibility in immune-related disorders like infections, autoimmunity, and malignancies. Various naturally available immunomodulators are also available which target immune pathways containing X chromosome genes.

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性别在免疫反应和表观遗传机制中的作用。

人类免疫系统的功能在很大程度上取决于个体的性别，这是性染色体和荷尔蒙差异造成的。表观遗传机制，如 X 染色体失活、镶嵌、倾斜以及 X 染色体基因和 Y 染色体调控基因的二态性，造成了男性和女性之间基于性别的免疫反应差异。这导致男性和女性对感染、自身免疫和恶性肿瘤等免疫相关疾病的易感性不同。目前也有各种天然的免疫调节剂，它们针对的是含有 X 染色体基因的免疫途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epigenetics & Chromatin GENETICS & HEREDITY-

CiteScore

7.00

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Epigenetics & Chromatin is a peer-reviewed, open access, online journal that publishes research, and reviews, providing novel insights into epigenetic inheritance and chromatin-based interactions. The journal aims to understand how gene and chromosomal elements are regulated and their activities maintained during processes such as cell division, differentiation and environmental alteration.