Beyond appearance: Can morphologically low-grade euploid blastocysts yield successful pregnancies?

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2024-01-18 eCollection Date: 2024-01-01 DOI:10.1002/rmb2.12560

Takahiro Suzuki, Chiharu Ishida, Yoko Yoshioka, Masae Kojima, Mikiko Tokoro, Noritaka Fukunaga, Yoshimasa Asada

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引用次数: 0

Abstract

Purpose: The primary objective of this investigation is to evaluate how morphological quality affects the pregnancy outcomes in euploid embryos determined by preimplantation genetic testing for aneuploidies (PGT-A). Concurrently, as a secondary objective, we aim to identify which specific aspects of morphological evaluation exert the most significant impact on these outcomes.

Methods: A retrospective analysis of 451 single euploid embryo transfer cycles at our clinic was conducted. Embryos were evaluated based on the degree of blastocyst expansion, inner cell mass (ICM), trophectoderm (TE) morphology, and the day of blastocyst vitrification. Outcomes between morphologically low-grade and high-grade embryos were compared. Additionally, the study analyzed which morphological factors most influenced pregnancy outcomes.

Results: Pregnancy outcomes were significantly lower in morphologically low-grade blastocysts compared to high-grade ones. Among the morphological evaluations, the ICM assessment was significantly associated with the live birth rate.

Conclusion: Our study indicates that the morphological quality of euploid embryos, particularly the evaluation of the ICM, plays a crucial role in IVF-ET success.

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超越外表：形态学上低级别的优倍囊胚能否成功妊娠？

目的：本研究的主要目的是评估形态学质量如何影响通过非整倍体胚胎植入前基因检测（PGT-A）确定的优倍体胚胎的妊娠结局。同时，作为次要目标，我们旨在确定形态学评估的哪些具体方面对这些结果产生了最重要的影响：方法：我们对本诊所的 451 个单倍体胚胎移植周期进行了回顾性分析。根据囊胚扩张程度、内细胞团（ICM）、滋养层（TE）形态和囊胚玻璃化日对胚胎进行评估。对形态学上低等级胚胎和高等级胚胎的结果进行了比较。此外，研究还分析了哪些形态学因素对妊娠结局影响最大：结果：形态学上低级别囊胚的妊娠结局明显低于高级别囊胚。在形态学评估中，ICM 评估与活产率明显相关：我们的研究表明，优胚的形态学质量，尤其是 ICM 的评估，对 IVF-ET 的成功起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.