Long-term plasticity of NMDA GluN2B (NR2B) receptor in anterior cingulate cortical synapses.

IF 2.8 3区 医学 Q2 NEUROSCIENCES
Min Zhuo
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引用次数: 0

Abstract

The anterior cingulate cortex (ACC) is a key cortical area for pain perception, emotional fear and anxiety. Cortical excitation is thought to be the major mechanism for chronic pain and its related emotional disorders such as anxiety and depression. GluN2B (or called NR2B) containing NMDA receptors play critical roles for such excitation. Not only does the activation of GluN2B contributes to the induction of the postsynaptic form of LTP (post-LTP), long-term upregulation of GluN2B subunits through tyrosine phosphorylation were also detected after peripheral injury. In addition, it has been reported that presynaptic NMDA receptors may contribute to the modulation of the release of glutamate from presynaptic terminals in the ACC. It is believed that inhibiting subtypes of NMDA receptors and/or downstream signaling proteins may serve as a novel therapeutic mechanism for future treatment of chronic pain, anxiety, and depression.

前扣带回皮质突触中 NMDA GluN2B (NR2B) 受体的长期可塑性。
前扣带回皮层(ACC)是感知疼痛、情绪恐惧和焦虑的关键皮层区域。皮层兴奋被认为是慢性疼痛及其相关情绪失调(如焦虑和抑郁)的主要机制。含有 NMDA 受体的 GluN2B(或称 NR2B)在这种兴奋中起着至关重要的作用。GluN2B 的激活不仅有助于诱导突触后形式的 LTP(post-LTP),而且在外周损伤后还检测到 GluN2B 亚基通过酪氨酸磷酸化长期上调。此外,有报道称突触前 NMDA 受体可能有助于调节 ACC 中突触前终端谷氨酸的释放。据信,抑制 NMDA 受体亚型和/或下游信号蛋白可作为未来治疗慢性疼痛、焦虑症和抑郁症的一种新型治疗机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular Pain
Molecular Pain 医学-神经科学
CiteScore
5.60
自引率
3.00%
发文量
56
审稿时长
6-12 weeks
期刊介绍: Molecular Pain is a peer-reviewed, open access journal that considers manuscripts in pain research at the cellular, subcellular and molecular levels. Molecular Pain provides a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field.
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