Delayed-Onset Endophthalmitis after Intravitreal Aflibercept Injection.

IF 1.2 Q3 OPHTHALMOLOGY

Journal of Current Ophthalmology Pub Date : 2023-12-21 eCollection Date: 2023-04-01 DOI:10.4103/joco.joco_134_22

Ali Akbarzadeh, Masoud Rahimi, Amin Zand, Khalil Ghasemi Falavarjani

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引用次数: 0

Abstract

Purpose: To describe delayed-onset infectious endophthalmitis 4 months after intravitreal aflibercept injection.

Methods: An 80-year-old female was referred with signs and symptoms of clinical endophthalmitis 4 months after intravitreal injection of aflibercept for choroidal neovascularization. Noninfectious causes of panuveitis were excluded and she was diagnosed with delayed-onset postinjection infectious endophthalmitis. Vitreous and aqueous specimens were prepared and antibiotics (vancomycin and ceftazidime) were injected intravitreally.

Results: Vitreous culture was positive for Staphylococcus epidermidis. During the 1^st month after the antibiotic injections, symptoms and signs of the patient improved and became stable during the 6-month follow-ups.

Conclusions: Delayed-onset infectious endophthalmitis can be presented following intravitreal injections. Late presentation of uveitis in postinjected eyes needs complete investigations to rule out infectious endophthalmitis as an ophthalmic emergency.

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玻璃体内注射阿弗利百普后的迟发性眼内炎

目的：描述玻璃体内注射阿弗利贝赛后4个月出现的迟发性感染性眼内炎：一名80岁的女性患者在因脉络膜新生血管而接受阿弗利百普玻璃体内注射4个月后，因临床眼内炎的症状和体征而被转诊。在排除了非感染性泛眼炎的病因后，她被诊断为注射后迟发性感染性眼内炎。准备了玻璃体和水样标本，并在玻璃体内注射了抗生素（万古霉素和头孢他啶）：结果：玻璃体培养表皮葡萄球菌呈阳性。在注射抗生素后的第一个月，患者的症状和体征有所改善，并在 6 个月的随访中趋于稳定：结论：玻璃体内注射后可出现迟发性感染性眼内炎。结论：玻璃体内注射后可能会出现迟发性感染性眼内炎，注射后出现葡萄膜炎的患者需要进行全面检查，以排除感染性眼内炎这一眼科急症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Current Ophthalmology OPHTHALMOLOGY-

CiteScore

2.50

自引率

6.70%

发文量

审稿时长

8 weeks

期刊介绍： Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.