Impact of Lipids and Vascular Damage on Early Atherosclerosis in Adolescents with Parental Premature Coronary Artery Disease.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE

High Blood Pressure & Cardiovascular Prevention Pub Date : 2024-01-01 Epub Date: 2024-01-22 DOI:10.1007/s40292-023-00617-x

María Del Rocío Martínez-Alvarado, Margarita Torres-Tamayo, Juan Gabriel Juárez-Rojas, Aida X Medina-Urrutia, Guillermo C Cardoso-Saldaña, Ángel Rene López-Uribe, Juan Reyes-Barrera, Esteban Jorge-Galarza

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引用次数: 0

Abstract

Aim: To assess the relationship of cardiovascular risk factors (CRFs) with carotid intima media thickness (IMT) in adolescents with a parental history of premature coronary artery disease (PCAD).

Methods: This cross-sectional study included 50 healthy adolescents, aged 14-18 years, both sexes, with a parental history of PCAD, that were compared to 50 controls without this history. Questionnaires regarding information of CRFs were applied. Blood chemistry analyses, included lipid profile, lipoprotein (a), low density lipoprotein (LDL) susceptibility to oxidation, and inflammatory cytokine levels. The IMT was evaluated by ultrasound.

Results: The mean age of all participants was 15.9 years. Anthropometric measurements, blood pressure, and lipid profile were similar in both groups. However, the parental history of PCAD group exhibited lower high density lipoprotein cholesterol concentrations, shorter LDL particle oxidation time, and higher lipoprotein (a) levels compared to the control group. IMT was significantly higher in adolescents with a parental history of PCAD compared to controls, (0.53 ± 0.04 mm vs 0.47 ± 0.02 mm, p = 0.001). Among adolescents with a parental history of PCAD, those with ≥ 3 CRFs had significantly higher IMT values (0.56 mm) than those with < 3 CRFs (0.52 mm) and controls (0.48 mm). Multivariable analyses identified that systolic blood pressure and parental history of PCAD explained 26.8% and 16.1% of the variation in IMT. Furthermore, body mass index, LDL-C, ApoB-100, triglycerides and lipoprotein (a) interact with blood pressure levels to explain the IMT values.

Conclusion: Adolescents with a parental history of PCAD had higher IMT values than the control group, primary explained by systolic blood pressure and the parental inheritance. Adolescents with parental history of PCAD and ≥ 3 CRFs exhibited the highest IMT values. Notably, lipids and systolic blood pressure jointly contribute to explain IMT in these adolescents.

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父母患有早发性冠状动脉疾病的青少年血脂和血管损伤对其早期动脉粥样硬化的影响

目的：评估父母有早发冠状动脉疾病（PCAD）病史的青少年的心血管风险因素（CRF）与颈动脉内膜厚度（IMT）的关系：这项横断面研究纳入了 50 名健康青少年，年龄在 14-18 岁之间，男女均有，他们的父母都有过 PCAD 病史，并与 50 名无 PCAD 病史的对照组进行了比较。研究采用了有关 CRFs 信息的调查问卷。血液化学分析包括血脂概况、脂蛋白（a）、低密度脂蛋白（LDL）氧化敏感性和炎症细胞因子水平。超声波对内径进行了评估：所有参与者的平均年龄为 15.9 岁。结果：所有参与者的平均年龄为 15.9 岁，两组的人体测量、血压和血脂情况相似。然而，与对照组相比，父母有 PCAD 病史组的高密度脂蛋白胆固醇浓度较低，低密度脂蛋白颗粒氧化时间较短，脂蛋白（a）水平较高。与对照组相比，父母有 PCAD 病史的青少年的内径明显更高（0.53 ± 0.04 mm vs 0.47 ± 0.02 mm，p = 0.001）。在父母有 PCAD 病史的青少年中，CRF ≥ 3 的青少年的 IMT 值（0.56 毫米）明显高于有结论的青少年：父母有 PCAD 病史的青少年比对照组的 IMT 值高，主要原因是收缩压和父母的遗传。父母有 PCAD 病史且 CRF ≥ 3 项的青少年的 IMT 值最高。值得注意的是，血脂和收缩压共同解释了这些青少年的IMT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.